{"id":"W4282825014","doi":"10.1016/j.celrep.2022.110947","title":"Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University; University Health Network; Princess Margaret Cancer Centre; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canada Research Chairs; Fondation CHU de Québec; Ontario Institute for Cancer Research; Canadian Institutes of Health Research; Université Laval","keywords":"Biology; Histone acetyltransferase; Cell biology; Chromatin; Transcription factor; Fusion gene; Histone; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006117465,0.0003070948,0.0001485668,0.0001705186,0.0001735513,0.0002517735,0.0002119252,0.0003105904,0.001190166],"category_scores_gemma":[0.00009217689,0.000151287,0.0001778089,0.0002173245,0.0002564193,0.0001276645,0.0002659753,0.0004817292,0.0004554754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005477092,"about_ca_system_score_gemma":0.0001862384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006018698,"about_ca_topic_score_gemma":0.0008135425,"domain_scores_codex":[0.9998778,0.00001239827,0.00001352116,0.00003455221,0.00003289752,0.00002891285],"domain_scores_gemma":[0.9999173,0.00001373427,0.00003112585,0.00001012409,0.000003283827,0.00002441622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003910787,0.000005868517,0.0002238381,0.000009832735,0.000002675134,0.00007398785,0.00000524195,0.00006987761,0.9989871,0.0001607797,0.00001543944,0.0004062738],"study_design_scores_gemma":[0.00001015351,0.00005680148,0.00261596,0.000002466772,0.000009465775,0.0004257952,0.00001857049,0.001173557,0.9924067,0.00004873905,0.003228879,0.000002963473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926824,0.0004597099,0.005272045,0.00008229609,0.00003357507,0.00001525648,0.0004891529,0.00009762013,0.0008679373],"genre_scores_gemma":[0.9958249,0.0001664543,0.001919854,0.0000180219,0.000002967166,0.00001228802,0.0005765129,0.00001727854,0.001461638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001190166,"threshold_uncertainty_score":0.003981471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01262525241187132,"score_gpt":0.233148282041668,"score_spread":0.2205230296297967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}