{"id":"W4282825014","doi":"10.1016/j.celrep.2022.110947","title":"Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University; University Health Network; Princess Margaret Cancer Centre; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canada Research Chairs; Fondation CHU de Québec; Ontario Institute for Cancer Research; Canadian Institutes of Health Research; Université Laval","keywords":"Biology; Histone acetyltransferase; Cell biology; Chromatin; Transcription factor; Fusion gene; Histone; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003214836,0.0001477674,0.0001531291,0.00002788297,0.0003965459,0.00001306469,0.0002642407,0.00005556585,0.00005124927],"category_scores_gemma":[0.00002419114,0.0001066769,0.0001375148,0.0001293868,0.00007038184,0.000002013312,0.0002841011,0.0001352979,0.000001599036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006678591,"about_ca_system_score_gemma":0.000116503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007994497,"about_ca_topic_score_gemma":0.00004220033,"domain_scores_codex":[0.998795,0.0001076441,0.0003374237,0.0003446803,0.0002111065,0.0002041495],"domain_scores_gemma":[0.9989207,0.00001120455,0.0002491527,0.0006895531,0.0000719242,0.00005740645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000071313,0.00007224221,0.0001479836,0.00002087439,0.00002511316,0.0000484697,0.0003768039,0.001714225,0.9927256,0.00001870509,0.002502668,0.002275963],"study_design_scores_gemma":[0.0002861662,0.0004059108,0.001386223,0.00001182966,0.00004775834,0.0004268618,0.001138072,0.0004055337,0.8538697,0.00008415377,0.1416772,0.0002605884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960526,0.000525585,0.000943426,0.0005059834,0.0002095673,0.0007599869,0.00002368993,0.000008109748,0.0009710148],"genre_scores_gemma":[0.997601,0.00009405212,0.0001879409,0.0002279781,0.00009416694,0.0001343967,0.0001293092,0.00002687862,0.001504237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1391746,"threshold_uncertainty_score":0.4350159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01262525241187132,"score_gpt":0.233148282041668,"score_spread":0.2205230296297967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}