{"id":"W4282826652","doi":"10.1126/sciimmunol.abp8966","title":"Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs","year":2022,"lang":"en","type":"article","venue":"Science Immunology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital; McGill University Health Centre","funders":"Chao Family Comprehensive Cancer Center; Instituto de Salud Carlos III; National Center for Research Resources; Fisher Center for Alzheimer's Research Foundation; Agence Nationale de la Recherche; National Institute of Allergy and Infectious Diseases; National Center for Advancing Translational Sciences; Medical Research Council; Mercatus Center, George Mason University; University of California, San Francisco; Novo Nordisk Fonden; European Commission; Ministerio de Ciencia e Innovación; Fundación Mapfre; Fondation pour la Recherche Médicale; Fondation du Souffle; Institut National de la Santé et de la Recherche Médicale; Hellenic Foundation for Research and Innovation; Georgia Clinical and Translational Science Alliance; National Cancer Institute; National Medical Research Council; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Agencia Estatal de Investigación; St. Giles Foundation; George Mason University; National Institutes of Health","keywords":"Coronavirus disease 2019 (COVID-19); Pneumonia; Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Medicine; Immunology; Biology; Outbreak; Internal medicine; Disease; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008225732,0.000179627,0.0003377058,0.0007004267,0.0005298686,0.00003282867,0.0007183937,0.00006698737,0.0001180043],"category_scores_gemma":[0.0004199025,0.0001521896,0.00003971168,0.003093049,0.0006026184,0.0002356552,0.0005402485,0.0006771951,0.0000710973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001059653,"about_ca_system_score_gemma":0.002225597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001317892,"about_ca_topic_score_gemma":0.00009586198,"domain_scores_codex":[0.9973767,0.0001009372,0.000311397,0.0006501553,0.0007077322,0.0008530152],"domain_scores_gemma":[0.9989158,0.0001185022,0.00009711587,0.0006192391,0.0001733521,0.00007601872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001284413,0.0003617382,0.7860926,0.00002258039,0.00002458585,0.0001331119,0.001092262,0.00002312824,0.2085938,0.0005139031,0.0001015839,0.001756229],"study_design_scores_gemma":[0.005645246,0.003451367,0.919318,0.00002260059,0.00002116117,0.0002161543,0.000838464,0.0002241266,0.007273055,0.000442098,0.06225576,0.0002919714],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956843,0.0003043709,0.00001537658,0.00203098,0.0004083641,0.0005033184,0.000005164106,0.00009281917,0.0009553628],"genre_scores_gemma":[0.9752639,0.000004804695,0.00009219332,0.02445559,0.00002251168,0.00006257284,0.000006678606,0.00002100462,0.00007073818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2013208,"threshold_uncertainty_score":0.6206111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02745244059376962,"score_gpt":0.335255374614914,"score_spread":0.3078029340211444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}