{"id":"W4282826652","doi":"10.1126/sciimmunol.abp8966","title":"Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs","year":2022,"lang":"en","type":"article","venue":"Science Immunology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital; McGill University Health Centre","funders":"Chao Family Comprehensive Cancer Center; Instituto de Salud Carlos III; National Center for Research Resources; Fisher Center for Alzheimer's Research Foundation; Agence Nationale de la Recherche; National Institute of Allergy and Infectious Diseases; National Center for Advancing Translational Sciences; Medical Research Council; Mercatus Center, George Mason University; University of California, San Francisco; Novo Nordisk Fonden; European Commission; Ministerio de Ciencia e Innovación; Fundación Mapfre; Fondation pour la Recherche Médicale; Fondation du Souffle; Institut National de la Santé et de la Recherche Médicale; Hellenic Foundation for Research and Innovation; Georgia Clinical and Translational Science Alliance; National Cancer Institute; National Medical Research Council; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Agencia Estatal de Investigación; St. Giles Foundation; George Mason University; National Institutes of Health","keywords":"Coronavirus disease 2019 (COVID-19); Pneumonia; Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Medicine; Immunology; Biology; Outbreak; Internal medicine; Disease; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001632972,0.0003870138,0.000408779,0.0003257872,0.000807355,0.0004149948,0.0001734831,0.0004688069,0.001623814],"category_scores_gemma":[0.0008307406,0.0003231653,0.0002963052,0.0002208911,0.0003172177,0.0003532648,0.0003098784,0.0005833674,0.0002881663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002974674,"about_ca_system_score_gemma":0.0002321233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001748639,"about_ca_topic_score_gemma":0.001273337,"domain_scores_codex":[0.999819,0.00002276256,0.00001492708,0.00004499665,0.00002255391,0.00007580954],"domain_scores_gemma":[0.9995785,0.00007812808,0.000119811,0.0000257757,0.00004191425,0.0001558232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008183877,0.0001515476,0.9763242,0.00002786687,0.00003088997,0.01097054,0.0004739639,0.00008278711,0.005484038,0.00005287487,0.0002513643,0.005331496],"study_design_scores_gemma":[0.0000933858,0.0031355,0.9511987,0.00002377754,0.00006066262,0.04119853,0.0007137095,0.0005911211,0.00189948,0.00008210236,0.0009860366,0.00001703305],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995866,0.00009894504,0.00004988987,0.00001903836,0.000004538918,0.000005790917,0.00002092314,0.000002729439,0.0002115582],"genre_scores_gemma":[0.9997191,0.00004314401,0.0000298845,0.00002610978,0.00001219051,0.000002952846,0.00004308743,9.09948e-7,0.0001226373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001748639,"threshold_uncertainty_score":0.005432189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02745244059376962,"score_gpt":0.335255374614914,"score_spread":0.3078029340211444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}