{"id":"W4282828730","doi":"10.1101/2022.06.13.495535","title":"CCR4-NOT subunit CCF-1/CNOT7 interacts with the PAL-1/CDX-1 transcription factor to regulate multiple stress responses in <i>Caenorhabditis elegans</i>","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; University of Minnesota; National Institutes of Health; Universities Space Research Association; National Science Foundation","keywords":"Gene knockdown; Caenorhabditis elegans; Biology; Transcription factor; Gene; RNA interference; Transcriptional regulation; Gene expression; Cell biology; Genetics; Molecular biology; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001182865,0.0004513212,0.0003012582,0.0002795447,0.0003468242,0.0003562883,0.0004219762,0.0003692993,0.001442794],"category_scores_gemma":[0.0001351227,0.0002285925,0.0004038873,0.00009353364,0.0002473656,0.0002106321,0.0003926488,0.0005639921,0.0006458007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009792611,"about_ca_system_score_gemma":0.0004278629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003930353,"about_ca_topic_score_gemma":0.007165254,"domain_scores_codex":[0.9998206,0.00001079808,0.0000101509,0.0000551568,0.0000642599,0.0000391067],"domain_scores_gemma":[0.9998816,0.00001042378,0.00002952336,0.00001380887,0.00002435816,0.00004023062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005485738,0.000008167737,0.0005803854,0.00003164889,0.000004966897,0.00007481314,0.000006497211,0.0000738055,0.9983649,0.00007052362,0.0001580767,0.000571461],"study_design_scores_gemma":[0.00003580243,0.00009882654,0.04394886,0.00002757994,0.00004065704,0.0004678979,0.00007308545,0.00600413,0.9394281,0.0001305008,0.009720464,0.00002410116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905094,0.001751024,0.004238156,0.0001945855,0.00008570745,0.00002659482,0.001011043,0.0002139024,0.001969641],"genre_scores_gemma":[0.9873618,0.0004615191,0.002928924,0.0001563459,0.00001271759,0.00003397806,0.002681814,0.00008573112,0.006277148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003930353,"threshold_uncertainty_score":0.007814944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01263608405058662,"score_gpt":0.2139225454470319,"score_spread":0.2012864613964453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}