{"id":"W4282828744","doi":"10.1002/cbic.202200039","title":"STAT Protein Thermal Shift Assays to Monitor Protein‐Inhibitor Interactions","year":2022,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Michael Smith Health Research BC","keywords":"stat; Protein–protein interaction; STAT3; Chemistry; Chemical biology; Computational biology; STAT1; Target protein; Drug discovery; Biochemistry; Biology; Cell biology; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007743178,0.001659941,0.0005339172,0.001020516,0.0005103233,0.0003857176,0.000629353,0.0007315473,0.004882349],"category_scores_gemma":[0.0005540707,0.0005466403,0.0007111304,0.0009921442,0.0004030838,0.0003963074,0.0004016634,0.002355488,0.001922334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004586577,"about_ca_system_score_gemma":0.0003637405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000419771,"about_ca_topic_score_gemma":0.00122192,"domain_scores_codex":[0.9984207,0.0003796799,0.0001324221,0.0002859169,0.0005845929,0.000196606],"domain_scores_gemma":[0.9992889,0.0002436601,0.0001666875,0.00007103122,0.0001394424,0.00009025325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009957582,0.0000933928,0.0001104733,0.00008049596,0.00001689106,0.00001858207,0.00002557616,0.0001069501,0.9980754,0.0001143853,0.0001450398,0.001113341],"study_design_scores_gemma":[0.00001172844,0.0003302926,0.0008457605,0.000005443782,0.00001452323,0.00007021488,0.0000152556,0.001431565,0.9954206,0.00004887625,0.001798483,0.000007263774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7092908,0.007119881,0.2620649,0.000633864,0.0005419952,0.0008482643,0.004277336,0.002160173,0.0130627],"genre_scores_gemma":[0.7386697,0.009888546,0.206955,0.0006794875,0.0001846092,0.002300528,0.01053679,0.0004467933,0.03033854],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.004882349,"threshold_uncertainty_score":0.01633304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02026324032651963,"score_gpt":0.2812884594108729,"score_spread":0.2610252190843533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}