{"id":"W4282832723","doi":"10.7554/elife.72418","title":"Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice","year":2022,"lang":"en","type":"article","venue":"eLife","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; University of Glasgow; Wellcome Trust; Wellcome","keywords":"CCR1; Chemokine receptor; Chemokine; Chemokine receptor CCR5; Biology; CCL21; CCR10; C-C chemokine receptor type 6; CCL13; CXCL2; Cell biology; CX3CL1; CC chemokine receptors; Receptor; CCL7; Receptor expression; Immunology; Inflammation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005609218,0.0002046257,0.0007480779,0.0003743731,0.0001810955,0.00001177687,0.0001443352,0.00009993547,0.003320726],"category_scores_gemma":[0.0001846752,0.0001966142,0.0004187978,0.001168246,0.00004953143,0.00005883139,0.0002159783,0.0003087133,0.000003866475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004231971,"about_ca_system_score_gemma":0.0001353604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001396316,"about_ca_topic_score_gemma":0.000004054292,"domain_scores_codex":[0.9977068,0.00008412033,0.0007110714,0.000408805,0.000820999,0.0002681913],"domain_scores_gemma":[0.9986668,0.00006898255,0.0004587544,0.0004171866,0.000229552,0.000158755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004792261,0.0008287597,0.08468346,0.00007686859,0.0009409358,0.00001635932,0.0006558763,0.001039738,0.9080672,0.00003267272,0.002609071,0.0005698048],"study_design_scores_gemma":[0.006409999,0.0004135362,0.003049834,0.0001546047,0.003172298,0.0000445482,0.00190044,0.1828552,0.7768881,0.000005923827,0.0244359,0.0006697007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963668,0.0001604673,0.001476784,0.0001428192,0.001255604,0.0002648883,0.0001050047,0.00005934494,0.0001682639],"genre_scores_gemma":[0.9911562,0.00001714869,0.006913725,0.0001381596,0.0003775522,0.00002046053,0.0007569245,0.00004578631,0.000574095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1818154,"threshold_uncertainty_score":0.9975904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02444827298439521,"score_gpt":0.2947576259785325,"score_spread":0.2703093529941373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}