{"id":"W4282833175","doi":"10.1016/j.isci.2022.104595","title":"Role of the DUB enzyme USP7 in dendritic arborization, neuronal migration, and autistic-like behaviors in mice","year":2022,"lang":"en","type":"article","venue":"iScience","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; McGill University","keywords":"Haploinsufficiency; XIAP; Autism; Biology; Pathogenesis; Dendritic spine; Gene knockdown; Phenotype; Neuroscience; Cell biology; Immunology; Apoptosis; Caspase; Medicine; Gene; Programmed cell death; Genetics; Hippocampal formation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002231579,0.0004512534,0.000240751,0.0007021169,0.0002331012,0.0004044138,0.0002576433,0.0006245021,0.001311181],"category_scores_gemma":[0.0001803317,0.0002533312,0.0003112995,0.000142402,0.0006492439,0.0002476715,0.0003397807,0.0007058097,0.0003327981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003492566,"about_ca_system_score_gemma":0.000290297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006403792,"about_ca_topic_score_gemma":0.001013929,"domain_scores_codex":[0.9997962,0.0000384323,0.00002623891,0.00004624136,0.0000593332,0.00003358931],"domain_scores_gemma":[0.9997056,0.00003303886,0.0001167049,0.00002163071,0.00001762578,0.0001054189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001100765,0.00002133855,0.0004634353,0.00002589074,0.000007916005,0.0001916505,0.0000174634,0.00007770989,0.9970521,0.0004526439,0.00005098089,0.001528784],"study_design_scores_gemma":[0.00004076233,0.0002788848,0.01374136,0.00002431023,0.00004525441,0.001665499,0.00007678195,0.002230026,0.9771199,0.0005597044,0.004204468,0.00001294907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894308,0.001598295,0.005220837,0.0002623665,0.00003008874,0.00001819577,0.0006062228,0.0002015299,0.002631717],"genre_scores_gemma":[0.9935032,0.00056493,0.00288596,0.00004901517,0.000007361646,0.00002246536,0.0003382474,0.00005979348,0.002569223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001311181,"threshold_uncertainty_score":0.004386365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004723714619532002,"score_gpt":0.2099559525818321,"score_spread":0.2052322379623001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}