{"id":"W4282835299","doi":"10.1002/etc.5396","title":"Alkylation of Benz[<i>a</i>]anthracene Affects Toxicity to Early–Life Stage Zebrafish and In Vitro Aryl Hydrocarbon Receptor 2 Transactivation in a Position-Dependent Manner","year":2022,"lang":"en","type":"article","venue":"Environmental Toxicology and Chemistry","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Saskatchewan; University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Conservation Association","keywords":"Aryl hydrocarbon receptor; Transactivation; Chemistry; Toxicity; Zebrafish; In vivo; Alkylation; Anthracene; In vitro; Environmental chemistry; Pharmacology; Stereochemistry; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001414712,0.0003709007,0.0001538526,0.0001667957,0.0001185028,0.0001677394,0.0001412063,0.0002505556,0.001702478],"category_scores_gemma":[0.0001498533,0.0001841034,0.0002621433,0.0001025646,0.0001789319,0.0001492972,0.0001378765,0.0002911546,0.000311808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004258691,"about_ca_system_score_gemma":0.0003616111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007045441,"about_ca_topic_score_gemma":0.01135663,"domain_scores_codex":[0.9998442,0.00002858837,0.00001873216,0.00002506425,0.0000538964,0.00002957873],"domain_scores_gemma":[0.9998832,0.0000176286,0.0000417562,0.000009431715,0.00003019551,0.0000179005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006287796,0.000007852706,0.00022509,0.00001183889,0.000003509259,0.00002284951,0.000007639989,0.00004219261,0.9993591,0.000007902771,0.0000173498,0.0002319291],"study_design_scores_gemma":[0.000008636476,0.0008480772,0.01375285,0.000005302653,0.00002142794,0.00008477081,0.00003010927,0.0003036735,0.9838502,0.00001250326,0.001075712,0.000006642669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962257,0.0007039363,0.000761002,0.0000632491,0.0000159735,0.00002362419,0.0005231171,0.00003596485,0.001647301],"genre_scores_gemma":[0.9908275,0.001184731,0.00135451,0.0000826121,0.000005441392,0.00003919745,0.001170565,0.00001430813,0.005321162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007045441,"threshold_uncertainty_score":0.01400888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003813520928488646,"score_gpt":0.1914661207364674,"score_spread":0.1876525998079788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}