{"id":"W4282836838","doi":"10.3390/toxins14060399","title":"Reductive Amination for LC–MS Signal Enhancement and Confirmation of the Presence of Caribbean Ciguatoxin-1 in Fish","year":2022,"lang":"en","type":"article","venue":"Toxins","topic":"Marine Toxins and Detection Methods","field":"Environmental Science","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Norges Forskningsråd; Universiteit Gent; National Science Foundation","keywords":"Derivatization; Chemistry; Ciguatoxin; Chromatography; Reductive amination; Selected reaction monitoring; Tandem mass spectrometry; Mass spectrometry; Orbitrap; Liquid chromatography–mass spectrometry; Triple quadrupole mass spectrometer; Fish <Actinopterygii>; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005106674,0.00004856364,0.00008415875,0.00003023945,0.00008223088,0.000003401051,0.0001028114,0.00001529625,0.001015667],"category_scores_gemma":[0.00005489787,0.00004167493,0.0000264766,0.0001895705,0.00009782224,0.00006949181,0.0001728114,0.00006316063,2.995164e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008003631,"about_ca_system_score_gemma":0.00001010267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004910717,"about_ca_topic_score_gemma":0.000276099,"domain_scores_codex":[0.9992703,0.0001294109,0.00018527,0.0001273139,0.0002080989,0.00007957845],"domain_scores_gemma":[0.9996421,0.00007866799,0.0001385702,0.0001155996,0.000009201734,0.00001584916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001818818,0.0003663463,0.02180665,0.00007032033,0.00001565643,3.70823e-7,0.006548034,0.01148457,0.8595899,0.001411538,0.001186091,0.09733865],"study_design_scores_gemma":[0.000660944,0.0004121431,0.1887171,0.000009902496,0.00001307121,0.000003414481,0.001134285,0.01687359,0.7850461,0.001866758,0.005143965,0.0001187325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901438,0.000005012651,0.005315394,0.0002383967,0.00008090232,0.000441394,0.00002924833,0.000003704329,0.003742159],"genre_scores_gemma":[0.9979346,0.000003023469,0.001386684,0.00003747586,0.000007256258,0.00007995988,0.000002749943,0.000003300718,0.0005449347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1669104,"threshold_uncertainty_score":0.9998975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01346752469330051,"score_gpt":0.2577232081360268,"score_spread":0.2442556834427263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}