{"id":"W4282838644","doi":"10.1128/msphere.00156-22","title":"Reconstitution of Mycobacterium marinum Nonhomologous DNA End Joining Pathway in <i>Leishmania</i>","year":2022,"lang":"en","type":"article","venue":"mSphere","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Ku80; Ku70; Biology; Non-homologous end joining; DNA ligase; DNA repair; Cell biology; DNA; Molecular biology; Genetics; Gene; DNA-binding protein; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002505838,0.0001135839,0.0001499914,0.00002816969,0.00006361899,0.000007222142,0.00018004,0.00008610042,0.0004863541],"category_scores_gemma":[0.00003183149,0.0001303771,0.00007032915,0.0001055743,0.00004596755,0.000003917587,0.0003114247,0.0001307154,0.000007482276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004248338,"about_ca_system_score_gemma":0.0001152226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000676011,"about_ca_topic_score_gemma":0.0001815731,"domain_scores_codex":[0.9990434,0.0001028372,0.000232381,0.0002919094,0.0001233053,0.0002061353],"domain_scores_gemma":[0.9995271,0.000007315922,0.0001053202,0.0002991937,0.00002558292,0.00003547113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008007685,0.00008713777,0.003832442,0.00002105663,0.00001655465,0.00003862757,0.00006719578,0.0001474357,0.9886058,0.000324992,0.0007928993,0.005985809],"study_design_scores_gemma":[0.0006659895,0.0005018436,0.001538136,0.00001376083,0.00000678076,0.0001255167,0.000353977,0.00005024515,0.9019641,0.0002487886,0.09430456,0.0002262654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842651,0.0002276674,0.0001470753,0.00005079553,0.000424005,0.0001500525,0.00005078263,0.00001775024,0.01466675],"genre_scores_gemma":[0.9977947,0.00001373167,0.0007151192,0.0002089361,0.00005968246,0.00005340231,0.0001208572,0.00001754969,0.001016055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09351166,"threshold_uncertainty_score":0.5325236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007692290524053368,"score_gpt":0.202797867801141,"score_spread":0.1951055772770876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}