{"id":"W4282839460","doi":"10.3389/fnins.2022.908650","title":"Alzheimer’s Disease-Related Genes Identified by Linking Spatial Patterns of Pathology and Gene Expression","year":2022,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Alzheimer's Association","keywords":"Biology; Gene; Alzheimer's Disease Neuroimaging Initiative; Gene expression; Neuroimaging; Pathogenesis; Neuroscience; Gene expression profiling; Amyloid beta; Microarray analysis techniques; Human brain; Genetics; Disease; Pathology; Computational biology; Alzheimer's disease; Medicine; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002398677,0.0002937022,0.0003160871,0.001091222,0.0002785754,0.000382148,0.0001513047,0.0002081364,0.001587937],"category_scores_gemma":[0.0005475996,0.00009748524,0.0004277631,0.001430665,0.0002959224,0.0001248587,0.0002637315,0.0002873503,0.0002909004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002691798,"about_ca_system_score_gemma":0.0004166702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00142541,"about_ca_topic_score_gemma":0.001620304,"domain_scores_codex":[0.9997885,0.00002380451,0.00001276394,0.00009519488,0.00003769254,0.00004217718],"domain_scores_gemma":[0.9996061,0.000132427,0.0001265166,0.00002640122,0.00006360411,0.0000449679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001708884,0.0002717311,0.4978314,0.0005386327,0.0004390618,0.000788652,0.0003039755,0.002989453,0.4452111,0.0008576002,0.001559843,0.04749956],"study_design_scores_gemma":[0.0000318309,0.0001883771,0.9685023,0.00001893189,0.0001603174,0.0008402821,0.0001748582,0.005473567,0.02138496,0.001054568,0.002152361,0.00001761356],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885995,0.0005445777,0.004762425,0.00007731845,0.00001027083,0.00003993575,0.004997356,0.00008421357,0.0008845236],"genre_scores_gemma":[0.9853328,0.0002726944,0.008364376,0.00005664012,0.00001091925,0.0001028145,0.005275041,0.00002036457,0.0005643768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001587937,"threshold_uncertainty_score":0.005312145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02360556908250724,"score_gpt":0.285216738545862,"score_spread":0.2616111694633548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}