{"id":"W4282842000","doi":"10.1101/2022.06.10.495369","title":"AAV-mediated neuronal expression of a scFv antibody selective for Aβ oligomers protects synapses and rescues memory in Alzheimer models","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Western University","funders":"Institute for Translational Neuroscience; International Society for Neurochemistry; Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo; Consejo Nacional de Investigaciones Científicas y Técnicas; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Company of Biologists; Alzheimer's Society","keywords":"Hippocampal formation; Long-term potentiation; Neuroscience; Antibody; Memory impairment; Chemistry; Biology; Medicine; Immunology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001101072,0.0002489447,0.0001798569,0.0002488616,0.0001138472,0.0001858609,0.0001590731,0.0003322769,0.001470054],"category_scores_gemma":[0.00006489486,0.00007871266,0.0001661718,0.0001122904,0.0001447628,0.00011171,0.00009635375,0.0004548934,0.0004899685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001865695,"about_ca_system_score_gemma":0.0001492438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009591965,"about_ca_topic_score_gemma":0.0008580888,"domain_scores_codex":[0.999946,0.000004160183,0.000004396368,0.00001112121,0.00001831766,0.00001589908],"domain_scores_gemma":[0.9999701,0.000003481445,0.00000633187,0.000003497371,0.000007133603,0.00000941385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005552694,0.00003130425,0.00008298698,0.00002026499,0.00000460915,0.00003289154,0.000007297107,0.00005558613,0.9975911,0.0001863187,0.0001925248,0.001739569],"study_design_scores_gemma":[0.00002458062,0.0001110449,0.001852196,0.000006477604,0.000008895993,0.0002253468,0.00001185358,0.001456383,0.9917383,0.0001291956,0.004433295,0.000002520483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802803,0.002037115,0.01121513,0.000300306,0.0001056178,0.0000367124,0.001003928,0.0003087136,0.004712105],"genre_scores_gemma":[0.9715726,0.001404933,0.007912682,0.0001408426,0.00003383553,0.00003847709,0.00161383,0.00007759374,0.01720531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001470054,"threshold_uncertainty_score":0.00491786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03151168166924601,"score_gpt":0.2943712462355661,"score_spread":0.2628595645663201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}