{"id":"W4282913510","doi":"10.1158/1538-7445.am2022-3755","title":"Abstract 3755: DNA methylation patterns, but not genetic sequence alterations, are concordant across multiply sampled sites within individuals with unilateral and bilateral Wilms tumors","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Hospital for Sick Children","funders":"","keywords":"Wilms' tumor; DNA methylation; Biology; Methylation; Malignancy; Pathology; Epigenomics; Cancer research; Genetics; DNA; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001361,0.0001565653,0.0002785962,0.0007636332,0.000302569,0.0002938083,0.0001524907,0.0001930973,0.00296048],"category_scores_gemma":[0.0009404406,0.0001274465,0.0001614857,0.0004338628,0.0002745722,0.0001189678,0.0003337567,0.0002037142,0.0002109472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002194942,"about_ca_system_score_gemma":0.00009311733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001939174,"about_ca_topic_score_gemma":0.003074746,"domain_scores_codex":[0.9996662,0.00003172855,0.00002826841,0.0001251891,0.000100234,0.00004845488],"domain_scores_gemma":[0.9995894,0.0001096544,0.0001369402,0.000038113,0.00003937094,0.00008663339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000877812,0.00003835613,0.7583183,0.00003407924,0.0001208963,0.00109578,0.0004984585,0.0002258763,0.2298367,0.0001215891,0.0002342048,0.008597962],"study_design_scores_gemma":[0.000007364291,0.0001080344,0.9883826,0.000003305295,0.00003122178,0.002499508,0.000125771,0.0002797482,0.008128565,0.00008140958,0.000345459,0.000007019554],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993466,0.00008283995,0.0001546844,0.000008670164,0.000001351529,0.000002177978,0.000188029,0.00000501438,0.0002106651],"genre_scores_gemma":[0.9995341,0.00001793868,0.0001219496,0.000007046708,0.000001659929,0.000003080546,0.0001839678,0.000004260997,0.0001260289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00296048,"threshold_uncertainty_score":0.009903789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05504365000334779,"score_gpt":0.3618875400657644,"score_spread":0.3068438900624166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}