{"id":"W4282913612","doi":"10.1158/1538-7445.am2022-5479","title":"Abstract 5479: Discovery and evaluation of GT19630, a c-Myc/GSPT1 cereblon E3 ligase modulator (CELMoD), for targeting Myc-driven blood cancers and small cell lung cancers (SCLC)","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Cancer research; Western blot; Biology; Cell growth; Cancer; Cell; Ubiquitin ligase; HL60; Molecular biology; Chemistry; Ubiquitin; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001610738,0.0004272195,0.0002696858,0.0001790828,0.00009497121,0.000187538,0.0002543692,0.0003689345,0.001504816],"category_scores_gemma":[0.00008675482,0.0001033737,0.000220377,0.000151563,0.000145893,0.0001530712,0.000157084,0.000429662,0.0007439138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002549303,"about_ca_system_score_gemma":0.0002186947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005322192,"about_ca_topic_score_gemma":0.0008854517,"domain_scores_codex":[0.9999466,0.000007712552,0.000005168185,0.00001053739,0.00001776776,0.00001225006],"domain_scores_gemma":[0.9999644,0.000002391642,0.000008349959,0.000003710632,0.000006282434,0.00001490976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004323765,0.0002413765,0.0002680441,0.00009316896,0.00001279045,0.000229628,0.00001831183,0.0005414216,0.9868687,0.0001773455,0.0004356474,0.01068123],"study_design_scores_gemma":[0.0005290534,0.009239887,0.002860588,0.00001748079,0.00004450385,0.001322185,0.00002265629,0.001640265,0.9718202,0.0000838882,0.01240638,0.00001285055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844544,0.003448804,0.003171126,0.0002881691,0.00005881646,0.0003613644,0.001275966,0.0001767033,0.006764594],"genre_scores_gemma":[0.9857612,0.002663487,0.003008883,0.0002012412,0.00001453448,0.00008417585,0.002433502,0.00001898259,0.005814035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001504816,"threshold_uncertainty_score":0.005034089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04418012339935042,"score_gpt":0.349968534002214,"score_spread":0.3057884106028636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}