{"id":"W4282913774","doi":"10.4049/jimmunol.2101090","title":"Translational Control by 4E-BP1/2 Suppressor Proteins Regulates Mitochondrial Biosynthesis and Function during CD8+ T Cell Proliferation","year":2022,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McGill University Health Centre; Princess Margaret Cancer Centre; McGill University; University Health Network","funders":"Canadian Institutes of Health Research; Ontario Institute for Cancer Research; Government of Canada","keywords":"Cell biology; Effector; Biology; PI3K/AKT/mTOR pathway; Derepression; Translation (biology); Cell growth; Cytotoxic T cell; CD28; T cell; Biogenesis; Protein biosynthesis; mTORC1; Mitochondrial biogenesis; Mitochondrion; Signal transduction; Gene; Molecular biology; Gene expression; Genetics; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000150662,0.0003985744,0.0001776463,0.000294384,0.0001650839,0.0003158859,0.0001518256,0.0002524075,0.000983738],"category_scores_gemma":[0.0001369676,0.0001328988,0.0001230592,0.000110646,0.0002670061,0.0001909958,0.0001770081,0.0004305243,0.0004690367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003577082,"about_ca_system_score_gemma":0.0001261013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002589212,"about_ca_topic_score_gemma":0.0004146954,"domain_scores_codex":[0.9998989,0.00002146845,0.000008530996,0.00002095814,0.00002200054,0.00002800273],"domain_scores_gemma":[0.9998469,0.0000223325,0.00005958293,0.00001310503,0.00001409285,0.000044001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000943365,0.000007643804,0.0001256062,0.00000481942,6.500709e-7,0.00001869765,0.000003929968,0.00002915063,0.9994557,0.00002621747,0.000009800818,0.0002234708],"study_design_scores_gemma":[0.0000131735,0.0001156786,0.005266814,0.000002307976,0.000004597134,0.0001349593,0.00001820423,0.0007708317,0.9929201,0.00005467425,0.0006959031,0.000002803319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979777,0.0005035164,0.0008790091,0.00005046856,0.0000099283,0.000006401614,0.0001408563,0.00005257578,0.0003796704],"genre_scores_gemma":[0.9976064,0.0001777934,0.0007688804,0.00001694038,0.000006902914,0.0000114281,0.0002590001,0.0000208558,0.001131778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000983738,"threshold_uncertainty_score":0.003290951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005169535929190869,"score_gpt":0.1880214090311414,"score_spread":0.1828518731019505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}