{"id":"W4282914372","doi":"10.1172/jci.insight.156372","title":"Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Warwick Medical School; Biotechnology and Biological Sciences Research Council; Medical Research Council; Directorate for Biological Sciences; St George's University Hospitals NHS Foundation Trust; Gilead Sciences; Oxford University Hospitals NHS Foundation Trust; University of Oxford; University of Warwick; Wellcome; Meso Scale Diagnostics; National Institute for Health and Care Research; Leona M. and Harry B. Helmsley Charitable Trust; Robertson Foundation; Wellcome Trust","keywords":"Epitope; Coronavirus; Antibody; Immune system; Virology; Immunology; Spike Protein; Medicine; Biology; Middle East respiratory syndrome coronavirus; Antigen; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Disease; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00104144,0.0003518491,0.0006350725,0.0003712169,0.0006990744,0.00009624561,0.0003978001,0.0001166453,0.0002625445],"category_scores_gemma":[0.002259571,0.0002519912,0.0001028539,0.0008353309,0.0002191782,0.0003350227,0.0002508973,0.0008100927,0.00002935948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008146805,"about_ca_system_score_gemma":0.001570785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005671225,"about_ca_topic_score_gemma":0.0003392737,"domain_scores_codex":[0.9962265,0.0007167392,0.0003766361,0.0006998418,0.001327288,0.0006529358],"domain_scores_gemma":[0.9977654,0.0009409837,0.0002596221,0.0005925106,0.0002243707,0.0002171141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01344712,0.0006932003,0.9184726,0.00006836515,0.0003153762,0.003253346,0.002965069,0.00002131389,0.05921709,0.00003964643,0.001369834,0.0001369839],"study_design_scores_gemma":[0.01235786,0.00635006,0.5157494,0.0001795133,0.0002380353,0.0003193294,0.007465475,0.0004272985,0.01874704,0.00004959232,0.4371409,0.0009755127],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961413,0.0004331382,0.0000729766,0.001357784,0.00009800975,0.0007427703,0.0002610539,0.0003609151,0.0005320157],"genre_scores_gemma":[0.948486,0.000002940711,0.0001639588,0.05050828,0.00008358324,0.0001653926,0.0002343074,0.00008868828,0.0002668062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.435771,"threshold_uncertainty_score":0.9999932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07234085318076522,"score_gpt":0.379740208876525,"score_spread":0.3073993556957598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}