{"id":"W4282914372","doi":"10.1172/jci.insight.156372","title":"Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Warwick Medical School; Biotechnology and Biological Sciences Research Council; Medical Research Council; Directorate for Biological Sciences; St George's University Hospitals NHS Foundation Trust; Gilead Sciences; Oxford University Hospitals NHS Foundation Trust; University of Oxford; University of Warwick; Wellcome; Meso Scale Diagnostics; National Institute for Health and Care Research; Leona M. and Harry B. Helmsley Charitable Trust; Robertson Foundation; Wellcome Trust","keywords":"Epitope; Coronavirus; Antibody; Immune system; Virology; Immunology; Spike Protein; Medicine; Biology; Middle East respiratory syndrome coronavirus; Antigen; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Disease; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002324629,0.0003548251,0.0002306142,0.0004329335,0.0003226875,0.0004190924,0.0001436751,0.0002588535,0.004084342],"category_scores_gemma":[0.001231405,0.0001027153,0.000159503,0.000238994,0.0002963468,0.0002057893,0.0004913871,0.0005691607,0.0002957681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002226992,"about_ca_system_score_gemma":0.000170684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007082394,"about_ca_topic_score_gemma":0.0008614353,"domain_scores_codex":[0.9997203,0.00004765503,0.00002329779,0.00005169068,0.00005241389,0.0001047045],"domain_scores_gemma":[0.9987532,0.0001451263,0.0006473503,0.00006668655,0.0001306703,0.00025693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006490818,0.00009948254,0.977605,0.0000366243,0.00003671119,0.001087371,0.0001001647,0.00006309231,0.01294694,0.00009468262,0.0004292027,0.006851702],"study_design_scores_gemma":[0.000007629501,0.0001774561,0.99615,0.000006451945,0.00001155294,0.001968472,0.00008828664,0.0001369313,0.001030728,0.00007981528,0.0003398389,0.000002934519],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975774,0.0001962778,0.0002082833,0.00006862979,0.00001484574,0.000008092,0.0001319847,0.00001723941,0.001777313],"genre_scores_gemma":[0.9994742,0.00004258322,0.00006438533,0.00003387637,0.00001891465,0.000003106636,0.0001449834,0.00000267327,0.0002152906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004084342,"threshold_uncertainty_score":0.01366353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07234085318076522,"score_gpt":0.379740208876525,"score_spread":0.3073993556957598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}