{"id":"W4282914444","doi":"10.1186/s12943-022-01603-y","title":"CBX2 shapes chromatin accessibility promoting AML via p38 MAPK signaling pathway","year":2022,"lang":"en","type":"article","venue":"Molecular Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Biology; Chromatin; Gene silencing; Epigenetics; Epigenome; Cancer research; Cell biology; Myeloid leukemia; Chromatin remodeling; Chromatin immunoprecipitation; DNA methylation; Genetics; Gene expression; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004328979,0.0001904593,0.0001651491,0.00004479351,0.000277714,0.000045016,0.0002853667,0.00008525046,0.0004238047],"category_scores_gemma":[0.00005011494,0.0002048473,0.0001329627,0.0001754598,0.00003870123,0.000005479898,0.000348956,0.0001663405,0.000003060373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008088921,"about_ca_system_score_gemma":0.0001549828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007462628,"about_ca_topic_score_gemma":0.00002837546,"domain_scores_codex":[0.9983162,0.0002021841,0.0002985179,0.0005538933,0.0003137219,0.0003155166],"domain_scores_gemma":[0.9993279,0.000008833913,0.0001690084,0.0003265659,0.00008160128,0.00008610119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000238021,0.00005851112,0.001508702,0.00003312518,0.00004154924,0.00001128163,0.0001174276,0.00345781,0.980545,0.00001482234,0.0000348619,0.01415315],"study_design_scores_gemma":[0.0003296691,0.0001720695,0.001702145,0.00001065694,0.00001935717,0.000002544466,0.00004169784,0.001655789,0.9809948,0.0003884959,0.01441209,0.0002706641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795344,0.006803222,0.01244174,0.0001483418,0.0001843284,0.000313233,0.00004638013,0.00002684898,0.0005015095],"genre_scores_gemma":[0.9978977,0.00004084355,0.0009378791,0.0003312964,0.000167686,0.0002546403,0.0001358156,0.00004569185,0.0001883847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01836336,"threshold_uncertainty_score":0.8353431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229302730544239,"score_gpt":0.271490322601145,"score_spread":0.2591972952957026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}