{"id":"W4282915372","doi":"10.1158/1538-7445.am2022-1079","title":"Abstract 1079: Anti-cancer efficacy of TH1902, a SORT1 docetaxel peptide-drug conjugate, against ovarian and endometrial cancers xenografts alone or in combination with carboplatin","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Theratechnologies (Canada)","funders":"","keywords":"Docetaxel; Ovarian cancer; Cancer research; Pharmacology; Carboplatin; Cancer; Peptide; Medicine; Apoptosis; Drug; Internal medicine; Chemotherapy; Cisplatin; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009417957,0.0003118243,0.00033678,0.0001944807,0.00009868637,0.0002005606,0.0001756154,0.0002892888,0.001532534],"category_scores_gemma":[0.00006329224,0.0001103413,0.0001881333,0.0001615658,0.0001151781,0.0001553266,0.00007862398,0.0004999302,0.0003060665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003177441,"about_ca_system_score_gemma":0.0002690987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001435922,"about_ca_topic_score_gemma":0.001398931,"domain_scores_codex":[0.9999342,0.00001323752,0.000006912743,0.00001046235,0.00001922942,0.00001598081],"domain_scores_gemma":[0.9999596,0.000006942622,0.000006838801,0.000004134393,0.000005876521,0.00001670386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001193099,0.0003087003,0.0001950718,0.00007653237,0.00001857137,0.00005738913,0.00001814786,0.0002740586,0.9935966,0.00009249306,0.000352641,0.003816713],"study_design_scores_gemma":[0.0002020281,0.003325633,0.001929874,0.00000450138,0.00003085702,0.0001317814,0.00001318407,0.001230135,0.991053,0.00001066886,0.002063536,0.000004816618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957473,0.001285401,0.0003942765,0.00008422909,0.00005906542,0.00004630698,0.0003856783,0.00006086125,0.001936853],"genre_scores_gemma":[0.9945679,0.0009168081,0.0008001761,0.00004325657,0.00001314001,0.00003071281,0.0006840585,0.00001656505,0.002927458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001532534,"threshold_uncertainty_score":0.005126834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06753017365991106,"score_gpt":0.3868384058936241,"score_spread":0.319308232233713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}