{"id":"W4282915660","doi":"10.1002/art.42246","title":"Risk Assessment for Hip and Knee Osteoarthritis Using Polygenic Risk Scores","year":2022,"lang":"en","type":"review","venue":"Arthritis & Rheumatology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"ReumaNederland; Erasmus Medisch Centrum; ZonMw; European Commission; Arthritis Society; Dutch Arthritis Society","keywords":"Medicine; Rotterdam Study; Cohort; Osteoarthritis; Odds ratio; Knee replacement; Cohort study; Confidence interval; Internal medicine; Overweight; Population; Physical therapy; Arthroplasty; Body mass index; Surgery; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007178258,0.001126759,0.0007639687,0.003464876,0.0003649662,0.001016458,0.0006501439,0.0006206636,0.001581482],"category_scores_gemma":[0.01557374,0.0003418016,0.002442433,0.003084436,0.000545749,0.0006483359,0.001189965,0.0008688014,0.0002182398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002918627,"about_ca_system_score_gemma":0.0004606138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004366699,"about_ca_topic_score_gemma":0.004021357,"domain_scores_codex":[0.9929879,0.004636723,0.0004760422,0.001102261,0.0006267891,0.0001702221],"domain_scores_gemma":[0.9893167,0.005838986,0.003254199,0.0008360787,0.0005152032,0.0002387706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002537514,0.00003619395,0.9815454,0.00009037313,0.002695699,0.0000716123,0.00004167992,0.001874578,0.0003264231,0.0001931282,0.0002372578,0.01263386],"study_design_scores_gemma":[0.00008907674,0.0005109916,0.9754326,0.00007503475,0.002151649,0.000717439,0.00007304996,0.01814033,0.0002699362,0.001864469,0.0006339299,0.00004150429],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.955166,0.005865495,0.0335486,0.000540856,0.000051184,0.0001263985,0.003058821,0.0001683252,0.001474329],"genre_scores_gemma":[0.9910598,0.0005496886,0.007195224,0.00005127555,0.00004285033,0.00004417717,0.0008897295,0.000007967105,0.0001593137],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.007178258,"threshold_uncertainty_score":0.03796273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02491083429692975,"score_gpt":0.3186639532965543,"score_spread":0.2937531189996246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}