{"id":"W4282915660","doi":"10.1002/art.42246","title":"Risk Assessment for Hip and Knee Osteoarthritis Using Polygenic Risk Scores","year":2022,"lang":"en","type":"review","venue":"Arthritis & Rheumatology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"ReumaNederland; Erasmus Medisch Centrum; ZonMw; European Commission; Arthritis Society; Dutch Arthritis Society","keywords":"Medicine; Rotterdam Study; Cohort; Osteoarthritis; Odds ratio; Knee replacement; Cohort study; Confidence interval; Internal medicine; Overweight; Population; Physical therapy; Arthroplasty; Body mass index; Surgery; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009733944,0.0005445968,0.001938885,0.0001779325,0.0007797632,0.00004153465,0.0002921679,0.0007529262,0.0001381661],"category_scores_gemma":[0.0009720059,0.0005760794,0.0006106409,0.0001424171,0.0002752117,0.000005498528,0.0004697911,0.0005073126,0.000008288036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007090635,"about_ca_system_score_gemma":0.000512563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003669647,"about_ca_topic_score_gemma":0.0004440045,"domain_scores_codex":[0.995687,0.001308403,0.001085543,0.001052178,0.0001262012,0.0007406899],"domain_scores_gemma":[0.997387,0.0005773217,0.001176342,0.0006289766,0.00007381832,0.0001565595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001209912,0.00003750459,0.008870637,0.0004848362,0.0003996233,0.000004918292,0.00001965281,0.000009184465,0.00000458337,0.0001540288,0.0008422715,0.9891607],"study_design_scores_gemma":[0.001318823,0.001062707,0.00046856,0.0005413008,0.00053955,0.001076544,0.00006761148,0.00006145025,0.000001321227,0.0007670659,0.9934515,0.0006435962],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02057926,0.9746145,0.001492269,0.00002209166,0.0007613918,0.001199521,0.001226132,0.00002590681,0.00007894787],"genre_scores_gemma":[0.003356722,0.9867445,0.007403424,0.00005276139,0.0001126259,0.000859772,0.001299499,0.000108927,0.00006178366],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9926092,"threshold_uncertainty_score":0.9996691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02491083429692975,"score_gpt":0.3186639532965543,"score_spread":0.2937531189996246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}