{"id":"W4282915753","doi":"10.1021/acs.jmedchem.1c01965","title":"Two-Photon Photodynamic Therapy Targeting Cancers with Low Carboxylesterase 2 Activity Guided by Ratiometric Fluorescence","year":2022,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Cancer Research Society","keywords":"Prodrug; Photodynamic therapy; Chemistry; Photosensitizer; Singlet oxygen; In vivo; Carboxylesterase; Phototoxicity; Pharmacology; Irinotecan; Fluorescence; Two-photon excitation microscopy; In vitro; Combinatorial chemistry; Cancer research; Biophysics; Cancer; Enzyme; Photochemistry; Biochemistry; Oxygen; Medicine; Organic chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001817604,0.000391574,0.0002115119,0.0001386835,0.00007238668,0.0002036795,0.0002567175,0.000407892,0.0009158424],"category_scores_gemma":[0.0001797354,0.0001318123,0.0002027125,0.000100811,0.0001841003,0.0002933946,0.0002425208,0.0003316474,0.0002898821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004004709,"about_ca_system_score_gemma":0.0001277636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003113838,"about_ca_topic_score_gemma":0.0004687427,"domain_scores_codex":[0.9998498,0.00002347935,0.000006946164,0.00005077846,0.00004730127,0.00002173155],"domain_scores_gemma":[0.9999379,0.00001860451,0.00002351708,0.000005549186,0.000007961633,0.000006534319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001983083,0.000007346946,0.00002821824,0.00002205561,0.000001602777,0.00001119138,0.000004313041,0.00008028034,0.9984851,0.00009445642,0.00003561715,0.001209873],"study_design_scores_gemma":[0.000004614577,0.00006743545,0.0001750738,0.000001016605,0.000002319141,0.00005533536,0.000002131742,0.001180017,0.9979441,0.00001542641,0.000550061,0.000002540731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9199567,0.003479374,0.07046144,0.0003478113,0.00006843171,0.0001183573,0.0002548093,0.0004028411,0.004910125],"genre_scores_gemma":[0.9694219,0.001138216,0.02511533,0.0001034307,0.00001767837,0.00007300919,0.0001133238,0.00002928688,0.003987832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009158424,"threshold_uncertainty_score":0.003063858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005633199987282338,"score_gpt":0.223314266542723,"score_spread":0.2176810665554407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}