{"id":"W4282915892","doi":"10.1158/1538-7445.am2022-ct250","title":"Abstract CT250: A first-in-human phase 1 study of NL-201 in patients with relapsed or refractory cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; CD8; Melanoma; Immunotherapy; Cancer; Refractory (planetary science); Cytotoxic T cell; Cancer immunotherapy; Dosing; Oncology; Internal medicine; Immune system; Cancer research; Immunology; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001386437,0.002427133,0.001657796,0.0005505959,0.0005391529,0.001106779,0.001364736,0.001602667,0.00569521],"category_scores_gemma":[0.000932692,0.0006003604,0.00105017,0.0004249253,0.001123852,0.0009091833,0.00038601,0.003449389,0.002027974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001440655,"about_ca_system_score_gemma":0.002347158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002264221,"about_ca_topic_score_gemma":0.004458908,"domain_scores_codex":[0.9996252,0.0001647929,0.0000172635,0.00006338389,0.00004309243,0.00008614529],"domain_scores_gemma":[0.9993004,0.0001206628,0.00008199498,0.00006141135,0.00005044915,0.0003851692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4245269,0.164242,0.01125218,0.001655194,0.001254179,0.001742903,0.0006606669,0.00664679,0.2175862,0.0007560935,0.01983226,0.1498447],"study_design_scores_gemma":[0.3214336,0.6447268,0.01174516,0.00006277737,0.000362754,0.001099697,0.00008589139,0.002079867,0.01278491,0.0001996772,0.005357127,0.00006181383],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984792,0.001870368,0.001073785,0.0007382449,0.0001496467,0.004279466,0.002787271,0.0003379118,0.003971335],"genre_scores_gemma":[0.9784153,0.001646202,0.002241125,0.001510419,0.0001838709,0.003354055,0.007176567,0.00008391302,0.005388566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00569521,"threshold_uncertainty_score":0.01905245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08198810902565855,"score_gpt":0.4348763330431794,"score_spread":0.3528882240175208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}