{"id":"W4282916913","doi":"10.1001/jama.2022.6147","title":"Effect of Metformin vs Placebo on Invasive Disease–Free Survival in Patients With Breast Cancer","year":2022,"lang":"en","type":"article","venue":"JAMA","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":223,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Alberta; Université Laval; Statistics Canada; Juravinski Cancer Centre; BC Cancer Agency; University of British Columbia; McMaster University; Queen's University; University of Toronto; Princess Margaret Cancer Centre; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"University College London Hospitals NHS Foundation Trust; North Bristol NHS Trust; University Hospitals Coventry and Warwickshire NHS Trust; Norfolk and Norwich University Hospitals NHS Foundation Trust; University of Sussex; National Institute for Health and Care Research; University College London; National Cancer Institute; Cancer Research UK; Inselspital, Universitätsspital Bern; Sandwell and West Birmingham Hospitals NHS Trust","keywords":"Medicine; Internal medicine; Breast cancer; Placebo; Oncology; Metformin; Cancer; Gynecology; Insulin; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002467964,0.001087155,0.00246002,0.0004255711,0.0003335922,0.0007778862,0.0005634452,0.00156547,0.003479798],"category_scores_gemma":[0.003960517,0.0004582869,0.002733945,0.0003675475,0.0007724992,0.001017045,0.0004661641,0.002069164,0.000327104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006811536,"about_ca_system_score_gemma":0.0009579713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005910373,"about_ca_topic_score_gemma":0.001454482,"domain_scores_codex":[0.9987685,0.0008319343,0.0001137676,0.0001279383,0.00005973059,0.00009801157],"domain_scores_gemma":[0.9982122,0.0007321695,0.0005243542,0.0001027589,0.00007341888,0.000355137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9843581,0.002383985,0.0008950227,0.0003196713,0.0006660064,0.0000162133,0.000018347,0.0001565649,0.0005594103,0.00002891411,0.0001914199,0.01040631],"study_design_scores_gemma":[0.7628756,0.2246552,0.008710749,0.00009522729,0.001586609,0.00003729016,0.00003858786,0.0006624264,0.0005684598,0.0002136727,0.0005355568,0.00002064364],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883862,0.008119248,0.0001857979,0.0005793949,0.0005538142,0.0007994745,0.0003530648,0.00003656153,0.00098656],"genre_scores_gemma":[0.9954523,0.001877867,0.0003581367,0.0004063653,0.0003692713,0.0007520602,0.0001997024,0.00000442601,0.0005797568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003479798,"threshold_uncertainty_score":0.01305199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003373661966268818,"score_gpt":0.2146638281215741,"score_spread":0.2112901661553053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}