{"id":"W4282916913","doi":"10.1001/jama.2022.6147","title":"Effect of Metformin vs Placebo on Invasive Disease–Free Survival in Patients With Breast Cancer","year":2022,"lang":"en","type":"article","venue":"JAMA","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":223,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Alberta; Université Laval; Statistics Canada; Juravinski Cancer Centre; BC Cancer Agency; University of British Columbia; McMaster University; Queen's University; University of Toronto; Princess Margaret Cancer Centre; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"University College London Hospitals NHS Foundation Trust; North Bristol NHS Trust; University Hospitals Coventry and Warwickshire NHS Trust; Norfolk and Norwich University Hospitals NHS Foundation Trust; University of Sussex; National Institute for Health and Care Research; University College London; National Cancer Institute; Cancer Research UK; Inselspital, Universitätsspital Bern; Sandwell and West Birmingham Hospitals NHS Trust","keywords":"Medicine; Internal medicine; Breast cancer; Placebo; Oncology; Metformin; Cancer; Gynecology; Insulin; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002263848,0.0001255971,0.000190061,0.00004368383,0.00003926759,0.000006753526,0.000207833,0.00003746631,0.0001600313],"category_scores_gemma":[0.0000768129,0.00009848059,0.00005558825,0.0001058673,0.00003518896,0.000004171122,0.0001389795,0.00009677922,0.000001254737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003620872,"about_ca_system_score_gemma":0.0001140974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001009443,"about_ca_topic_score_gemma":0.0001251538,"domain_scores_codex":[0.9990097,0.0001821768,0.0001220172,0.000239436,0.0002651617,0.0001814822],"domain_scores_gemma":[0.999449,0.00003539749,0.0000816278,0.0003170261,0.00004848127,0.00006853484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02720289,0.0003981331,0.7250745,0.0002132536,0.0001825548,0.000008125757,0.0000961516,0.0009748755,0.001668558,0.00007036626,0.005724581,0.238386],"study_design_scores_gemma":[0.02135443,0.003339403,0.8469148,0.00008383855,0.0001254252,8.605541e-7,0.00005460279,0.00001836104,0.07807139,0.0000368171,0.04951852,0.0004816012],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926119,0.005827657,0.000001197952,0.00003376349,0.0001946373,0.0002972494,0.0007969643,0.000003489922,0.000233104],"genre_scores_gemma":[0.9985027,0.0005946957,0.000005267043,0.0002654547,0.0001168477,0.0002265689,0.0001744563,0.00001932257,0.00009469073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2379044,"threshold_uncertainty_score":0.4015922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003373661966268818,"score_gpt":0.2146638281215741,"score_spread":0.2112901661553053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}