{"id":"W4282917096","doi":"10.1128/jvi.00509-22","title":"Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity","year":2022,"lang":"en","type":"article","venue":"Journal of Virology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Sinai Health System; Health Sciences Centre; Lunenfeld-Tanenbaum Research Institute; St. Michael's Hospital; National Research Council Canada; York University; University of Toronto","funders":"Canadian Institutes of Health Research; Ontario HIV Treatment Network; Government of Canada","keywords":"Biology; Persistence (discontinuity); Virology; Immunology; CD8; T cell; Immunity; Disease; Coronavirus; Cytokine; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Immune system; Epitope; Antibody; Infectious disease (medical specialty); Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005838433,0.0002469947,0.0003229807,0.0003394248,0.0002531887,0.0003462328,0.0001291391,0.0003964386,0.001335892],"category_scores_gemma":[0.000583601,0.00009983583,0.0002327814,0.0001964567,0.0001466275,0.0002967966,0.0002172118,0.0007152614,0.00037742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001727869,"about_ca_system_score_gemma":0.0002343004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008784981,"about_ca_topic_score_gemma":0.001596426,"domain_scores_codex":[0.9998211,0.00003463923,0.00001721837,0.00004609027,0.00002959182,0.00005148532],"domain_scores_gemma":[0.9994152,0.00007592599,0.0002011475,0.00006576639,0.0001220735,0.0001199049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002749549,0.0008164701,0.2324431,0.0001184148,0.0001002009,0.0004242381,0.0004482313,0.0003724843,0.7346432,0.00008050336,0.0004471076,0.02735654],"study_design_scores_gemma":[0.00004099111,0.007319027,0.9125084,0.00002567096,0.000128638,0.001203513,0.0003777375,0.000923534,0.07550126,0.000123053,0.001820516,0.0000275955],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969446,0.0004173332,0.0009485466,0.00005846889,0.00001422394,0.00004146334,0.0006334807,0.00004732571,0.0008943786],"genre_scores_gemma":[0.9973042,0.0001409862,0.0003828736,0.00007136334,0.000009695555,0.00003869751,0.0009428198,0.000004217568,0.001105112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001335892,"threshold_uncertainty_score":0.004468977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09276472056387124,"score_gpt":0.3650442775717224,"score_spread":0.2722795570078511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}