{"id":"W4282917599","doi":"10.1164/rccm.202110-2274oc","title":"Macrophage–NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension","year":2022,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":204,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; Queen's University","funders":"National Center for Advancing Translational Sciences; Cardiovascular Medical Research and Education Fund; Canada Foundation for Innovation; National Heart, Lung, and Blood Institute; University of Minnesota; National Institutes of Health; United Therapeutics Corporation","keywords":"Medicine; Inflammasome; Pulmonary hypertension; Right ventricular hypertrophy; Heart failure; Internal medicine; Macrophage; Pulmonary fibrosis; Lung; Ventricle; Pulmonary artery; Fibrosis; Endocrinology; Cardiology; Pathology; Immunology; Inflammation; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000283935,0.0001480195,0.0005203094,0.000325346,0.000180629,0.000006862598,0.00009715129,0.00003583013,0.0003369758],"category_scores_gemma":[0.0006175285,0.0001050573,0.00008690749,0.0005339166,0.0004516664,0.000121851,0.000091224,0.0005629672,0.000001275199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001663694,"about_ca_system_score_gemma":0.0001960712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002801529,"about_ca_topic_score_gemma":0.000001593076,"domain_scores_codex":[0.9979941,0.0003292616,0.0004121522,0.0002242007,0.0007621355,0.0002781157],"domain_scores_gemma":[0.9988595,0.0001619277,0.0001269215,0.0001654141,0.0002957092,0.0003905133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.009496043,0.003015441,0.2599515,0.0004368003,0.0001553754,0.08508362,0.0007869794,0.000008257507,0.4427129,0.0002047656,0.002106026,0.1960422],"study_design_scores_gemma":[0.01926577,0.05372687,0.8039451,0.001855188,0.0005964421,0.02672281,0.02489004,0.000182762,0.01668095,0.0007517317,0.05071403,0.0006683123],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914615,0.001655423,0.000008755124,0.006319885,0.000194606,0.0001856134,0.00000867361,0.000008596146,0.0001569634],"genre_scores_gemma":[0.9974604,0.00002075809,0.0001252215,0.002077038,0.0002649884,0.0000101747,0.000005963369,0.00001612019,0.0000193226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5439936,"threshold_uncertainty_score":0.4284111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01933641249494837,"score_gpt":0.3008057388897813,"score_spread":0.281469326394833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}