{"id":"W4282919200","doi":"10.1176/appi.ajp.21090964","title":"Flexible Buprenorphine/Naloxone Model of Care for Reducing Opioid Use in Individuals With Prescription-Type Opioid Use Disorder: An Open-Label, Pragmatic, Noninferiority Randomized Controlled Trial","year":2022,"lang":"en","type":"article","venue":"American Journal of Psychiatry","topic":"Opioid Use Disorder Treatment","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Buprenorphine; Opioid use disorder; Medicine; Methadone; Randomized controlled trial; (+)-Naloxone; Opioid; Anesthesia; Randomization; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001544845,0.0004271279,0.003655667,0.0005998618,0.0002347141,0.0001293802,0.0005185404,0.00006309956,0.00006239016],"category_scores_gemma":[0.0005846366,0.0003201616,0.0003335694,0.0006767355,0.0002479583,0.0007935108,0.0001490239,0.000569567,4.501291e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002281488,"about_ca_system_score_gemma":0.002829385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001729942,"about_ca_topic_score_gemma":0.0002963131,"domain_scores_codex":[0.9954618,0.0007992504,0.002002653,0.0004420496,0.0008666844,0.0004275501],"domain_scores_gemma":[0.9952843,0.0005784259,0.002607443,0.0006376071,0.0006260982,0.0002661486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.923721,0.006831698,0.0491986,0.0002041793,0.001508214,0.000006657493,0.006970793,0.009770673,0.000315741,0.0003855382,0.0001971436,0.0008897299],"study_design_scores_gemma":[0.9540902,0.02748559,0.001826674,0.000441619,0.00213515,0.00005742883,0.00823963,0.004689928,0.00003053704,0.0005320936,0.0001286932,0.0003424174],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842499,0.001811153,0.002529347,0.0007591481,0.0008917005,0.0094908,0.0002064443,0.00002514854,0.00003634199],"genre_scores_gemma":[0.8268252,0.0003432771,0.1711217,0.0002720545,0.0001739873,0.0008804971,0.0001622401,0.00009457385,0.0001264514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1685924,"threshold_uncertainty_score":0.999925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0208297750802206,"score_gpt":0.3082555854637435,"score_spread":0.2874258103835229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}