{"id":"W4282919200","doi":"10.1176/appi.ajp.21090964","title":"Flexible Buprenorphine/Naloxone Model of Care for Reducing Opioid Use in Individuals With Prescription-Type Opioid Use Disorder: An Open-Label, Pragmatic, Noninferiority Randomized Controlled Trial","year":2022,"lang":"en","type":"article","venue":"American Journal of Psychiatry","topic":"Opioid Use Disorder Treatment","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Buprenorphine; Opioid use disorder; Medicine; Methadone; Randomized controlled trial; (+)-Naloxone; Opioid; Anesthesia; Randomization; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005624262,0.002371518,0.003762941,0.0007911896,0.001154398,0.001524387,0.001706376,0.003306124,0.006161176],"category_scores_gemma":[0.005475505,0.00108059,0.003299321,0.0007637965,0.001921534,0.001180315,0.0008487607,0.002690419,0.0005299837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002655214,"about_ca_system_score_gemma":0.006036488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01501665,"about_ca_topic_score_gemma":0.03209588,"domain_scores_codex":[0.9965279,0.002103108,0.0002644022,0.000402451,0.0003823815,0.0003197467],"domain_scores_gemma":[0.9978257,0.000594934,0.0004880098,0.0001922508,0.0002759781,0.000623116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.968447,0.010399,0.0003784941,0.00171005,0.001984124,0.00003386989,0.0001066451,0.0002375456,0.0009292972,0.0001265625,0.0004573014,0.01519022],"study_design_scores_gemma":[0.9746565,0.02379874,0.0005577781,0.0000582348,0.0004139094,0.000008858099,0.00001535853,0.0001711596,0.00006752495,0.00006041306,0.0001816042,0.00001000866],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9137174,0.007991979,0.002323378,0.001693081,0.00124981,0.06657502,0.001746346,0.0002504976,0.00445262],"genre_scores_gemma":[0.9526413,0.003436835,0.008258693,0.00172507,0.0006168139,0.03037746,0.0006693932,0.00002144182,0.002253075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01501665,"threshold_uncertainty_score":0.02985847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0208297750802206,"score_gpt":0.3082555854637435,"score_spread":0.2874258103835229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}