{"id":"W4282919436","doi":"10.1097/der.0000000000000905","title":"Dupilumab for Atopic Dermatitis—From Clinical Trials to Molecular and Cellular Mechanisms","year":2022,"lang":"en","type":"article","venue":"Dermatitis","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Dupilumab; Atopic dermatitis; Medicine; Clinical trial; Adverse effect; Monoclonal antibody; Immunology; Dermatology; Monoclonal; Antibody; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001735628,0.0005579893,0.001235545,0.0008328684,0.0002123181,0.001425843,0.000501636,0.0009047471,0.003079696],"category_scores_gemma":[0.001266622,0.0001740308,0.0008056448,0.0005995033,0.0004110223,0.001014033,0.0005730011,0.00223887,0.0007816029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005306939,"about_ca_system_score_gemma":0.0006022608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003152433,"about_ca_topic_score_gemma":0.001063083,"domain_scores_codex":[0.9995721,0.0001628868,0.0000561577,0.0000523099,0.0001163488,0.00004024287],"domain_scores_gemma":[0.9993881,0.0003459223,0.0000755714,0.00001905798,0.0001045451,0.00006679923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002469146,0.000371819,0.0003685949,0.01592166,0.0004168584,0.0002942292,0.0001156439,0.0003185178,0.005890768,0.004295953,0.01666885,0.952868],"study_design_scores_gemma":[0.003563818,0.007987738,0.00443389,0.02589049,0.001756353,0.002442861,0.0001981668,0.0006168796,0.005732345,0.007940802,0.9393631,0.00007362927],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001881783,0.9950811,0.0001652323,0.0009443702,0.0002775186,0.00003332738,0.00004419942,0.00001279741,0.00155974],"genre_scores_gemma":[0.0225949,0.9704345,0.0008082871,0.003682907,0.001078984,0.0000906629,0.0001382554,0.00001046673,0.001160935],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003079696,"threshold_uncertainty_score":0.01030254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04569087154652571,"score_gpt":0.3478375384441518,"score_spread":0.3021466668976261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}