{"id":"W4282921879","doi":"10.1139/cjpp-2022-0006","title":"The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line","year":2022,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Adenocarcinoma; Gene silencing; Cancer research; Survivin; A549 cell; Lung cancer; Apoptosis; Lung; Downregulation and upregulation; Epithelial–mesenchymal transition; Cancer; Biology; Medicine; Pathology; Internal medicine; Metastasis; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002308052,0.0002645837,0.0004363619,0.0002410316,0.0003014133,0.0002560472,0.0001872846,0.0003788069,0.002625168],"category_scores_gemma":[0.0001124801,0.000154302,0.0004173363,0.0004890339,0.00013302,0.0001914173,0.0001456466,0.0007480693,0.0007057422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002770477,"about_ca_system_score_gemma":0.0002852948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002468708,"about_ca_topic_score_gemma":0.002461982,"domain_scores_codex":[0.9996805,0.00004141851,0.00004789132,0.00005420973,0.000127445,0.00004861535],"domain_scores_gemma":[0.9999186,0.00001876032,0.00001000664,0.00001438078,0.00002204058,0.00001626572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001832575,0.0001272579,0.0002860075,0.00009472369,0.00001521084,0.0001169578,0.00003968979,0.00008891596,0.9966497,0.0001253552,0.0005069575,0.001766081],"study_design_scores_gemma":[0.0001131831,0.0009758651,0.008295766,0.00001323726,0.00005361216,0.0006118598,0.00008229635,0.001856933,0.9776365,0.00008023034,0.010266,0.00001456212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729931,0.008558965,0.005287443,0.0007162877,0.0003455535,0.0001339158,0.005114842,0.0002161021,0.006633773],"genre_scores_gemma":[0.9668106,0.005085292,0.007148519,0.000436182,0.00003828401,0.0003462953,0.00758358,0.00004312963,0.01250818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002625168,"threshold_uncertainty_score":0.008782089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009261655338378078,"score_gpt":0.2922939807563345,"score_spread":0.2830323254179564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}