{"id":"W4282922005","doi":"10.1158/1078-0432.ccr-20-4774","title":"Identification of Two Genetic Loci Associated with Leukopenia after Chemotherapy in Patients with Breast Cancer","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Neutropenia and Cancer Infections","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"National Human Genome Research Institute; National Cancer Institute; National Institutes of Health; Eli Lilly and Company; Universitätsklinikum Erlangen; National Institute of General Medical Sciences; Sanofi; AstraZeneca; Chugai Pharmaceutical; Breast Cancer Research Foundation","keywords":"Genome-wide association study; Biology; Locus (genetics); Genotyping; Breast cancer; Genotype; Chemotherapy; Genetic association; Genetics; Gene; Oncology; Cancer; Medicine; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003799035,0.0002626517,0.0002628095,0.0003811593,0.0002280392,0.0003904096,0.0002335521,0.0004365239,0.001356859],"category_scores_gemma":[0.001444988,0.0001288634,0.0003247509,0.0006843611,0.0002094227,0.0001077508,0.000236982,0.0003181545,0.0001348478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002115043,"about_ca_system_score_gemma":0.0002189279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001356475,"about_ca_topic_score_gemma":0.001672647,"domain_scores_codex":[0.9996691,0.00009070771,0.00003895342,0.0001032773,0.00005335962,0.00004453875],"domain_scores_gemma":[0.9993989,0.0001383888,0.0003254224,0.00004568661,0.00003347094,0.00005808331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001038823,0.00006553053,0.9889278,0.00003757797,0.0002093975,0.0002302958,0.00004625199,0.0001505009,0.005159133,0.00004605796,0.0001102873,0.003978217],"study_design_scores_gemma":[0.00005166952,0.0001429004,0.998108,0.000008501629,0.0001135517,0.0004618533,0.00003796673,0.0002754185,0.0005595867,0.00006186379,0.0001752731,0.000003296482],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991278,0.0002971079,0.0001596058,0.00004935006,0.00000376256,0.000005217723,0.0002036679,0.000004473852,0.0001490518],"genre_scores_gemma":[0.9994741,0.00005602078,0.0001610474,0.00002763443,0.000004636923,0.00000500585,0.0001858414,0.000001653295,0.00008415498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001356859,"threshold_uncertainty_score":0.004539192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06316643415099286,"score_gpt":0.4527562737164417,"score_spread":0.3895898395654488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}