{"id":"W4282923240","doi":"10.1182/bloodadvances.2022007493","title":"Single-cell spatial analysis of tumor immune architecture in diffuse large B-cell lymphoma","year":2022,"lang":"en","type":"article","venue":"Blood Advances","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; University of Southern California","keywords":"Immune system; Diffuse large B-cell lymphoma; Tumor microenvironment; Lymphoma; Cancer research; Biology; Immune checkpoint; Cancer; Immunology; Immunotherapy; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001434381,0.00009620291,0.0001560925,0.0006310022,0.0001129111,0.000247951,0.00008509921,0.0001598189,0.0002031571],"category_scores_gemma":[0.0001670244,0.0001036702,0.00006805338,0.000273872,0.000144769,0.0001214005,0.0001589087,0.0001228784,0.0000730508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002132343,"about_ca_system_score_gemma":0.00006792022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008053231,"about_ca_topic_score_gemma":0.001524845,"domain_scores_codex":[0.99993,0.00001337204,0.000004434503,0.00002067206,0.00001731035,0.00001419232],"domain_scores_gemma":[0.999917,0.00001834571,0.00002060389,0.00001156395,0.00001741218,0.00001501752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001173515,0.00001737201,0.02183196,0.00003029431,0.00001070715,0.0001085,0.00007319716,0.0008923602,0.9701489,0.00007754419,0.00002040602,0.006671316],"study_design_scores_gemma":[0.00002155233,0.0002765054,0.2906498,0.000008951182,0.00006238116,0.001927954,0.0005038105,0.04508869,0.6595926,0.0003591942,0.00148835,0.00002011411],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948294,0.0003522031,0.004474196,0.00001097459,9.015303e-7,0.00001026647,0.0000628202,0.00003734247,0.000221943],"genre_scores_gemma":[0.994722,0.0001160621,0.004988987,0.000008557257,0.000002057992,0.00001101901,0.00006485507,0.00000466802,0.00008176429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008053231,"threshold_uncertainty_score":0.001601279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00533178578607884,"score_gpt":0.2019639306737186,"score_spread":0.1966321448876397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}