{"id":"W4282924000","doi":"10.1111/cts.13318","title":"An association study of <scp><i>ABCG2</i></scp> rs2231142 on the concentrations of allopurinol and its metabolites","year":2022,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Canadian Institutes of Health Research","keywords":"Allopurinol; Uric acid; Gout; Pharmacology; Hyperuricemia; Medicine; Abcg2; Metabolite; Pharmacokinetics; Internal medicine; Endocrinology; Chemistry; Biochemistry; Transporter; ATP-binding cassette transporter; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000588233,0.0005834356,0.0005122831,0.00060299,0.0006612332,0.0006445638,0.0005277671,0.0006420004,0.002634268],"category_scores_gemma":[0.001996124,0.0002893895,0.0006854904,0.001279692,0.0003396976,0.0001449715,0.0002936737,0.0005781306,0.0002525058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007280927,"about_ca_system_score_gemma":0.0005820798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0708345,"about_ca_topic_score_gemma":0.04194068,"domain_scores_codex":[0.9993984,0.0001757444,0.00003765739,0.0002098124,0.00009083548,0.00008770239],"domain_scores_gemma":[0.9984308,0.0003618283,0.0004894079,0.0002013111,0.0002085082,0.0003081333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001218247,0.00009710957,0.990986,0.0000225873,0.0006877503,0.0005009893,0.0001346403,0.00007405906,0.003707475,0.00005418871,0.0003063615,0.002210523],"study_design_scores_gemma":[0.00006810787,0.0002382075,0.9982923,0.000004603943,0.0002135584,0.0002827017,0.00003392193,0.0002547211,0.0002091446,0.00001971072,0.000377162,0.00000590322],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986528,0.0001931625,0.0001276078,0.00007138913,0.000011525,0.00001904036,0.0005391783,0.000008873966,0.0003763328],"genre_scores_gemma":[0.9989888,0.00007090311,0.0001541902,0.00005990243,0.00002831969,0.00001435124,0.0002913249,0.000005860205,0.0003863561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0708345,"threshold_uncertainty_score":0.1408443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05692373840182821,"score_gpt":0.35277759678218,"score_spread":0.2958538583803518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}