{"id":"W4282924823","doi":"10.1038/s41598-022-13388-7","title":"Caveolin-initiated macropinocytosis is required for efficient silica nanoparticles’ transcytosis across the alveolar epithelial barrier","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"University of Michigan; Cumming School of Medicine, University of Calgary; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Alberta Innovates; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs; National Science Foundation","keywords":"Transcytosis; Cell biology; Exocytosis; Endocytosis; Internalization; Chemistry; Mucociliary clearance; Pinocytosis; Biophysics; Secretion; Biology; Cell; Biochemistry; Lung; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001529061,0.000152087,0.0002005717,0.0001118798,0.0002557505,0.0003869815,0.0002022247,0.000358226,0.000855575],"category_scores_gemma":[0.0001729097,0.0001775095,0.0003784066,0.00007156218,0.0002153219,0.0002822086,0.0003182856,0.0004904958,0.0003736403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004600322,"about_ca_system_score_gemma":0.0003676046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001468411,"about_ca_topic_score_gemma":0.002152458,"domain_scores_codex":[0.9997969,0.000019187,0.00001843366,0.00004264916,0.00005670279,0.00006601701],"domain_scores_gemma":[0.9998705,0.00002319616,0.00003112983,0.00001819104,0.00002335834,0.00003359988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002786515,0.000005063826,0.0001934075,0.00001503033,0.000002457547,0.00006756012,0.00001164358,0.00001755518,0.9992076,0.0001230187,0.00001749977,0.0003113075],"study_design_scores_gemma":[0.00001347087,0.00007586083,0.0284449,0.000008399371,0.00001680796,0.0006355579,0.00007119414,0.003317223,0.9640693,0.0001375838,0.00319792,0.00001175401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951644,0.0006729715,0.003027708,0.00009239927,0.00001923139,0.00001453483,0.0001266876,0.0000676539,0.0008144722],"genre_scores_gemma":[0.9969267,0.0002121148,0.001176266,0.00003480211,0.000003491472,0.00001470066,0.0002336039,0.0000178153,0.001380588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001468411,"threshold_uncertainty_score":0.003337741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01868524564960757,"score_gpt":0.2727608005574997,"score_spread":0.2540755549078922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}