{"id":"W4282924823","doi":"10.1038/s41598-022-13388-7","title":"Caveolin-initiated macropinocytosis is required for efficient silica nanoparticles’ transcytosis across the alveolar epithelial barrier","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"University of Michigan; Cumming School of Medicine, University of Calgary; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Alberta Innovates; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs; National Science Foundation","keywords":"Transcytosis; Cell biology; Exocytosis; Endocytosis; Internalization; Chemistry; Mucociliary clearance; Pinocytosis; Biophysics; Secretion; Biology; Cell; Biochemistry; Lung; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.001776669,0.0002481379,0.0002276717,0.0000510588,0.00220793,0.0002412913,0.0004309849,0.0000995673,0.0002262099],"category_scores_gemma":[0.0001538756,0.0002042868,0.0003922559,0.0004526524,0.0004363506,0.000007442627,0.0003120242,0.0001435391,0.000009586097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004333553,"about_ca_system_score_gemma":0.000312287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003543072,"about_ca_topic_score_gemma":0.00003064099,"domain_scores_codex":[0.9968606,0.0001107094,0.0006073758,0.001137182,0.0005947115,0.0006894778],"domain_scores_gemma":[0.9980949,0.00002888849,0.0002709209,0.001173872,0.0002701411,0.0001612585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001380227,0.0001382851,0.0003013252,0.00003090478,0.00005851174,0.00004483274,0.001208339,0.0007099702,0.9899272,0.00001643162,0.006438283,0.0009878639],"study_design_scores_gemma":[0.0003868915,0.0001328259,0.0000519338,0.000005078994,0.0000505348,0.0002164213,0.0006215405,0.0003164856,0.7726988,0.000364004,0.2249159,0.000239579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932202,0.001243342,0.0006448109,0.0005289792,0.002969236,0.0007673578,0.0003839879,0.00004026707,0.000201852],"genre_scores_gemma":[0.9943206,0.00001646236,0.00007740741,0.0005503727,0.0001844047,0.0004418603,0.0003874324,0.00004517128,0.003976304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2184777,"threshold_uncertainty_score":0.9990911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01868524564960757,"score_gpt":0.2727608005574997,"score_spread":0.2540755549078922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}