{"id":"W4282925091","doi":"10.1093/ndt/gfac198","title":"Design of the COmbinatioN effect of FInerenone anD EmpaglifloziN in participants with chronic kidney disease and type 2 diabetes using a UACR Endpoint study (CONFIDENCE)","year":2022,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"School of Medicine, University of North Carolina at Chapel Hill; Defense Acquisition Program Administration; University of Chicago Medicine; Chugai Pharmaceutical; Vifor Pharma; Akebia Therapeutics; Rijksuniversiteit Groningen; Bayer HealthCare; Institut National de la Santé et de la Recherche Médicale; National Institutes of Health; Dexcom; Duke Clinical Research Institute; Astellas Pharma; Fresenius Medical Care North America; MannKind Corporation; McGill University; Relypsa; University of Chicago; Novo Nordisk; Vertex Pharmaceuticals; Bayer, United Kingdom; University of Connecticut; Alexion Pharmaceuticals; GlaxoSmithKline; Washington University in St. Louis; Alnylam Pharmaceuticals; Daiichi Sankyo Europe; Bayer; Gilead Sciences; European Commission; Kyowa Hakko Kirin; Sanofi; Amgen; Université de Lorraine; School of Medicine, Duke University; Pfizer; Celgene; AstraZeneca; Eli Lilly and Company","keywords":"Empagliflozin; Medicine; Type 2 diabetes; Kidney disease; Diabetes mellitus; Benzhydryl compounds; Confidence interval; Internal medicine; Clinical endpoint; Intensive care medicine; Randomized controlled trial; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.013646,0.002520701,0.003147016,0.0005884439,0.0006519837,0.001322836,0.001460377,0.002195965,0.004863793],"category_scores_gemma":[0.007451839,0.0010772,0.005192776,0.0006605514,0.0009215035,0.0008897239,0.001332405,0.002455929,0.0008367455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000761455,"about_ca_system_score_gemma":0.002367719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001377664,"about_ca_topic_score_gemma":0.001751533,"domain_scores_codex":[0.9905624,0.006217391,0.0005909823,0.001514804,0.0005814586,0.000532945],"domain_scores_gemma":[0.9964109,0.0008758963,0.0009391829,0.0004744574,0.0005775745,0.0007220816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9646721,0.00916406,0.009321609,0.00070111,0.003981289,0.00003269952,0.00007956672,0.0007489258,0.00229349,0.0002423414,0.0009018698,0.007860901],"study_design_scores_gemma":[0.6811047,0.2574109,0.04076384,0.0001128121,0.009730949,0.00008757624,0.00006659203,0.003060045,0.001937168,0.0007697297,0.004847898,0.0001076246],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9052166,0.003094994,0.008239264,0.0008338239,0.001059462,0.0671749,0.008198104,0.0002633849,0.005919518],"genre_scores_gemma":[0.8599479,0.0006978097,0.01618156,0.001459478,0.0006434725,0.113022,0.00482774,0.00004412373,0.003175994],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.013646,"threshold_uncertainty_score":0.07216781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02392562176676758,"score_gpt":0.2699735930730673,"score_spread":0.2460479713062997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}