{"id":"W4282925091","doi":"10.1093/ndt/gfac198","title":"Design of the COmbinatioN effect of FInerenone anD EmpaglifloziN in participants with chronic kidney disease and type 2 diabetes using a UACR Endpoint study (CONFIDENCE)","year":2022,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"School of Medicine, University of North Carolina at Chapel Hill; Defense Acquisition Program Administration; University of Chicago Medicine; Chugai Pharmaceutical; Vifor Pharma; Akebia Therapeutics; Rijksuniversiteit Groningen; Bayer HealthCare; Institut National de la Santé et de la Recherche Médicale; National Institutes of Health; Dexcom; Duke Clinical Research Institute; Astellas Pharma; Fresenius Medical Care North America; MannKind Corporation; McGill University; Relypsa; University of Chicago; Novo Nordisk; Vertex Pharmaceuticals; Bayer, United Kingdom; University of Connecticut; Alexion Pharmaceuticals; GlaxoSmithKline; Washington University in St. Louis; Alnylam Pharmaceuticals; Daiichi Sankyo Europe; Bayer; Gilead Sciences; European Commission; Kyowa Hakko Kirin; Sanofi; Amgen; Université de Lorraine; School of Medicine, Duke University; Pfizer; Celgene; AstraZeneca; Eli Lilly and Company","keywords":"Empagliflozin; Medicine; Type 2 diabetes; Kidney disease; Diabetes mellitus; Benzhydryl compounds; Confidence interval; Internal medicine; Clinical endpoint; Intensive care medicine; Randomized controlled trial; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000420189,0.00008155124,0.0002861426,0.0001387567,0.00006621458,0.000002727414,0.00002845372,0.00002519196,0.00003111296],"category_scores_gemma":[0.0000474499,0.00005503003,0.00002065517,0.0002710174,0.00009282602,0.00004066611,0.00001188747,0.00008234087,9.594434e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003043397,"about_ca_system_score_gemma":0.0001146615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007451775,"about_ca_topic_score_gemma":0.00007205755,"domain_scores_codex":[0.9988515,0.0004916434,0.0002115598,0.000149406,0.0001934149,0.0001024663],"domain_scores_gemma":[0.9995142,0.0001843603,0.0001020136,0.0001001979,0.00004286605,0.00005640648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00607626,0.0003275792,0.8135366,0.0002109272,0.0002029877,0.00002604315,0.002422007,0.007281133,0.1690569,0.00003159559,0.000002606833,0.0008253652],"study_design_scores_gemma":[0.004907266,0.002360283,0.9389644,0.00005219337,0.001599152,0.000008148783,0.0000641784,0.04764751,0.00430291,0.00003967455,0.000001871845,0.00005242922],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998598,0.0002657753,0.0002089179,0.000204027,0.00001773766,0.0006902386,0.000008340316,0.00000528211,0.000001684035],"genre_scores_gemma":[0.9997302,0.00006835271,0.00003415165,0.00008897656,0.000006107455,0.00003369671,0.00002910842,0.000006614485,0.00000284617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.164754,"threshold_uncertainty_score":0.2244059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02392562176676758,"score_gpt":0.2699735930730673,"score_spread":0.2460479713062997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}