{"id":"W4282925834","doi":"10.1158/1538-7445.am2022-1506","title":"Abstract 1506: <i>APOBEC3A a</i> causative agent in cancer-related chromosomal instability and STING driven metastasis","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Cancer research; Cancer; Chromosome instability; Cytidine deaminase; Pancreatic cancer; Downregulation and upregulation; Biology; Metastasis; Medicine; Genetics; Gene; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001048492,0.0002439047,0.0001718168,0.0002160689,0.0002070071,0.0002694257,0.0001680506,0.0004721128,0.005206221],"category_scores_gemma":[0.00008983383,0.00007119679,0.0002172965,0.0001454968,0.0002409087,0.0001274624,0.0002105909,0.0005780446,0.001285645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004177451,"about_ca_system_score_gemma":0.0001887184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001235857,"about_ca_topic_score_gemma":0.0007705792,"domain_scores_codex":[0.9999157,0.0000129908,0.000007550476,0.00002240672,0.00002124011,0.00002013408],"domain_scores_gemma":[0.9999274,0.00001118757,0.00001920365,0.000007919658,0.00001001118,0.00002433046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001599132,0.00003912784,0.0009743669,0.00005822785,0.000007723746,0.0006180505,0.00001251114,0.00004493483,0.9952806,0.0003135873,0.0004963072,0.0019946],"study_design_scores_gemma":[0.00003173429,0.0006218625,0.02702535,0.00002648092,0.00003643555,0.008425547,0.00007077646,0.001348793,0.9430786,0.0003839156,0.01893993,0.00001063593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737971,0.004023411,0.006545234,0.0007645909,0.0001883757,0.0001240673,0.002724268,0.0004144998,0.01141828],"genre_scores_gemma":[0.9893764,0.0008079236,0.001416998,0.0002012824,0.00003075157,0.00003021136,0.001048866,0.00003055198,0.00705697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005206221,"threshold_uncertainty_score":0.01741654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08661240975080152,"score_gpt":0.4002168849203093,"score_spread":0.3136044751695077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}