{"id":"W4282926624","doi":"10.1038/s41586-022-04787-x","title":"ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids","year":2022,"lang":"en","type":"article","venue":"Nature","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Cancer Institute; Diabetes Canada; National Institutes of Health; Austrian Science Fund; Boston Nutrition Obesity Research Center, Boston University; JPB Foundation","keywords":"Adipose triglyceride lipase; Adipose tissue; Biochemistry; Enzyme; Biosynthesis; Phospholipase; Diglyceride; Chemistry; Diacylglycerol kinase; Triglyceride; Lipase; Biology; Cholesterol","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001177254,0.0006317135,0.0004271022,0.0004055125,0.0003086348,0.0005399277,0.0002785523,0.0006279889,0.001347105],"category_scores_gemma":[0.0001222506,0.0001965309,0.0005018571,0.0003320752,0.000288716,0.0003100945,0.0003006401,0.0005309873,0.002811003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007334201,"about_ca_system_score_gemma":0.0003242723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003895877,"about_ca_topic_score_gemma":0.0002288003,"domain_scores_codex":[0.9998512,0.00001575346,0.00001626534,0.00005544222,0.00003887778,0.00002245938],"domain_scores_gemma":[0.9999037,0.0000115073,0.00003063399,0.000009480226,0.00002089123,0.0000238165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001877861,0.00003132826,0.000756908,0.000197575,0.0000146813,0.0002131482,0.00001647606,0.0001835913,0.9913658,0.0004877586,0.0005146385,0.006030377],"study_design_scores_gemma":[0.00004392962,0.0001643713,0.003678517,0.00001877066,0.00003415612,0.00091123,0.00003090387,0.001568586,0.9684046,0.0003351442,0.02479761,0.00001224272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8682345,0.03725131,0.07147959,0.001882087,0.00115439,0.0002413497,0.007531702,0.004858547,0.007366638],"genre_scores_gemma":[0.9371164,0.007200153,0.0268323,0.0004226216,0.0001315233,0.0001362782,0.01284867,0.0001449424,0.01516703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001347105,"threshold_uncertainty_score":0.005321383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007063559445586447,"score_gpt":0.2389282738738474,"score_spread":0.2318647144282609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}