{"id":"W4282927325","doi":"10.1158/1538-7445.am2022-ct126","title":"Abstract CT126: A phase 2 trial of first-line AZD0171 + durvalumab and chemotherapy (CT) in patients with metastatic pancreatic ductal adenocarcinoma (PDAC) and CD8+ T cell infiltration","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Durvalumab; Tumor microenvironment; Response Evaluation Criteria in Solid Tumors; CD8; Oncology; Cancer research; Immune system; Internal medicine; Immunotherapy; Phases of clinical research; Cancer; Chemotherapy; Immunology; Nivolumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001094431,0.001570358,0.001745445,0.0003970286,0.0003894518,0.001008622,0.0009767564,0.001296455,0.005803611],"category_scores_gemma":[0.000750854,0.0005607174,0.001176575,0.000431834,0.0009028905,0.0007324695,0.0003482233,0.003349968,0.00114239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001520534,"about_ca_system_score_gemma":0.001699281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001358313,"about_ca_topic_score_gemma":0.005319843,"domain_scores_codex":[0.9996531,0.0001697073,0.00001583649,0.00005937191,0.00003640897,0.0000655332],"domain_scores_gemma":[0.999564,0.00005292715,0.00006989469,0.00003139256,0.00003019937,0.0002515761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7710804,0.03434161,0.006205587,0.001421548,0.001945059,0.0003971277,0.0002320547,0.003656811,0.07727586,0.0005522823,0.0121609,0.09073084],"study_design_scores_gemma":[0.6451831,0.3291048,0.01040469,0.00006770816,0.0006829081,0.0005231376,0.00005021352,0.001950698,0.006087937,0.0001886972,0.005709589,0.00004640932],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851046,0.003356415,0.0005839939,0.001015621,0.0002842063,0.002659456,0.002931495,0.0002140124,0.003850225],"genre_scores_gemma":[0.980921,0.002074334,0.001543836,0.001036299,0.0002515994,0.002283764,0.005896284,0.00004000924,0.00595277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005803611,"threshold_uncertainty_score":0.01941502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0599190100686973,"score_gpt":0.3801356541263284,"score_spread":0.3202166440576311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}