{"id":"W4282929594","doi":"10.1158/1538-7445.am2022-5333","title":"Abstract 5333: Pancreatic cancer enhances HER2 signaling through DUSP6 to circumvent therapeutic MAPK inhibition","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Phenomenome Discoveries (Canada)","funders":"","keywords":"MAPK/ERK pathway; Cancer research; DUSP6; Trametinib; Downregulation and upregulation; Kinase; KRAS; PI3K/AKT/mTOR pathway; MEK inhibitor; Afatinib; Pancreatic cancer; Cancer; Chemistry; Medicine; Signal transduction; Phosphorylation; Internal medicine; Erlotinib; Phosphatase; Protein phosphatase 2; Epidermal growth factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000131219,0.0003963207,0.0002946929,0.0001572781,0.0001209715,0.0002820736,0.0001931446,0.0002143729,0.002056051],"category_scores_gemma":[0.00007847724,0.00010564,0.0002435273,0.0001910752,0.0001286463,0.00017047,0.000161586,0.0007993235,0.000496301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002892375,"about_ca_system_score_gemma":0.0002465782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003902062,"about_ca_topic_score_gemma":0.0006781103,"domain_scores_codex":[0.9999001,0.00001705428,0.000009857182,0.0000178384,0.00002726898,0.00002783451],"domain_scores_gemma":[0.9999669,0.000004973596,0.000007749848,0.000005117752,0.000005682355,0.000009636503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002476965,0.0001069644,0.0002273296,0.0000888164,0.0000111657,0.00005092593,0.000008908349,0.000181655,0.9931498,0.0001075205,0.0002868363,0.00553251],"study_design_scores_gemma":[0.00006016301,0.0009132205,0.002499776,0.000008118211,0.00002426773,0.0004135763,0.00001377545,0.001193794,0.9902277,0.0000409084,0.004600807,0.000003721917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894748,0.002998331,0.002884419,0.0002653449,0.00006530454,0.00007277374,0.0008959355,0.0002221126,0.003120989],"genre_scores_gemma":[0.991827,0.001412865,0.002625569,0.00009222203,0.00001354523,0.00005542842,0.001177002,0.00002181133,0.002774449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002056051,"threshold_uncertainty_score":0.006878197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07713922568351408,"score_gpt":0.4210816922919836,"score_spread":0.3439424666084695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}