{"id":"W4282930530","doi":"10.1093/genetics/iyac086","title":"Fine-tuning acetyl-CoA carboxylase 1 activity through localization: functional genomics reveals a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization","year":2022,"lang":"en","type":"article","venue":"Genetics","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Ottawa Hospital Research Institute; Canadian Institutes of Health Research; University of Ottawa","keywords":"Pyruvate carboxylase; Acetyl-CoA carboxylase; Biology; Biochemistry; Fatty acid synthesis; Mutant; Acetyltransferase; Fatty acid; Enzyme; Gene; Acetylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001132352,0.0005366783,0.0003192392,0.0002635246,0.0001710141,0.0003895268,0.0004695155,0.0003940616,0.0006855325],"category_scores_gemma":[0.000108026,0.0002405261,0.0003372774,0.000205466,0.0003640935,0.0002172082,0.000360633,0.0005363633,0.0002840902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004813339,"about_ca_system_score_gemma":0.0002709502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001650705,"about_ca_topic_score_gemma":0.002044485,"domain_scores_codex":[0.9999048,0.000009230084,0.000008630026,0.00003142552,0.00002676101,0.00001915784],"domain_scores_gemma":[0.9998871,0.00001794566,0.0000454528,0.0000115831,0.00001021869,0.00002768909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004872509,0.000008491274,0.0001189401,0.00001211656,0.000002323265,0.00001467635,0.000004363219,0.00007420625,0.9991975,0.0000378671,0.000007629756,0.0004730784],"study_design_scores_gemma":[0.00002081353,0.000111058,0.01170812,0.000006674367,0.00003249352,0.0002673917,0.0000460534,0.003251211,0.9828953,0.00009678662,0.001551416,0.00001270651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992937,0.0008636721,0.004946874,0.0001253503,0.0000141392,0.00001586322,0.0004955606,0.000124878,0.0004766233],"genre_scores_gemma":[0.9908746,0.0009163815,0.005498717,0.00007475805,0.00000645615,0.00003068315,0.0007518313,0.00007254496,0.001773908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001650705,"threshold_uncertainty_score":0.003492355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01151349929267834,"score_gpt":0.2217500949608919,"score_spread":0.2102365956682136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}