{"id":"W4282931075","doi":"10.1038/s41467-022-30926-z","title":"Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Moonshot Research and Development Program; JST-Mirai Program; Exploratory Research for Advanced Technology; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Ono Medical Research Foundation; Japan Agency for Medical Research and Development; Japan Science and Technology Agency; Uehara Memorial Foundation; Japan Foundation for Applied Enzymology","keywords":"Urea cycle; Nicotinamide; Methyltransferase; Biology; Biogenesis; Metabolism; Host (biology); Metabolic pathway; Biochemistry; Homeostasis; Urea; Carcinogen; Chemistry; Cancer research; Cell biology; Amino acid; Enzyme; Gene; Genetics; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002959394,0.0001740525,0.0001760978,0.00008022598,0.0009297131,0.00002792188,0.001403784,0.0001750104,0.0001401693],"category_scores_gemma":[0.00007306907,0.0001897326,0.0001560517,0.0003755197,0.0001382503,0.000007282427,0.0004773289,0.0008323914,0.000009163034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001309252,"about_ca_system_score_gemma":0.0002852273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003479229,"about_ca_topic_score_gemma":0.0008342473,"domain_scores_codex":[0.9985988,0.0003197148,0.0002746433,0.0003402483,0.000215872,0.0002507746],"domain_scores_gemma":[0.9970744,0.00003615222,0.0001137076,0.002516695,0.0001656704,0.00009335853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001299931,0.0003181887,0.001547056,0.00002124665,0.0004091625,0.000002736141,0.0004271237,0.001012394,0.9524713,0.003974947,0.01567162,0.02401422],"study_design_scores_gemma":[0.0006370657,0.000112789,0.002357611,0.000008301907,0.0001389142,0.00003826068,0.0003007399,0.002268786,0.03516981,0.0006817303,0.9578379,0.0004480784],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7902935,0.1692342,0.007975194,0.01583341,0.001217885,0.001542768,0.001112446,0.0001733106,0.01261725],"genre_scores_gemma":[0.9888273,0.003871785,0.003729005,0.001660216,0.0001084807,0.0002032648,0.0009095989,0.00004096617,0.0006494038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9421663,"threshold_uncertainty_score":0.7737072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01054657229788831,"score_gpt":0.286367481729522,"score_spread":0.2758209094316337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}