{"id":"W4282931075","doi":"10.1038/s41467-022-30926-z","title":"Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Moonshot Research and Development Program; JST-Mirai Program; Exploratory Research for Advanced Technology; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Ono Medical Research Foundation; Japan Agency for Medical Research and Development; Japan Science and Technology Agency; Uehara Memorial Foundation; Japan Foundation for Applied Enzymology","keywords":"Urea cycle; Nicotinamide; Methyltransferase; Biology; Biogenesis; Metabolism; Host (biology); Metabolic pathway; Biochemistry; Homeostasis; Urea; Carcinogen; Chemistry; Cancer research; Cell biology; Amino acid; Enzyme; Gene; Genetics; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008733219,0.0002680038,0.0002090546,0.0001647794,0.0001199121,0.0003247336,0.0001265611,0.0001849316,0.0007051498],"category_scores_gemma":[0.00008705416,0.00008581494,0.0001931303,0.00009355666,0.0001971514,0.0001610145,0.0002493799,0.0003513177,0.0001568459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003140623,"about_ca_system_score_gemma":0.0001505746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007749762,"about_ca_topic_score_gemma":0.002068925,"domain_scores_codex":[0.9999219,0.00001011303,0.000004734536,0.00002180426,0.0000244005,0.00001699527],"domain_scores_gemma":[0.999934,0.000005914591,0.00002547263,0.000008962719,0.000008206423,0.00001745638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006730719,0.000007601202,0.001000525,0.00002442566,0.000008204246,0.00005019259,0.000008097768,0.00006199647,0.9965867,0.0001543533,0.00003154495,0.001999095],"study_design_scores_gemma":[0.000009988972,0.0002734195,0.01831821,0.0000101898,0.00002896451,0.0004689492,0.00005416197,0.001428541,0.9744984,0.0002249913,0.004677601,0.000006674867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888645,0.003085307,0.00580591,0.0001801487,0.00004001429,0.0000155081,0.0002723362,0.0002023242,0.001533942],"genre_scores_gemma":[0.9958479,0.0008507051,0.00161005,0.00003824028,0.00000447658,0.000008609032,0.0002018053,0.00001061887,0.001427512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007749762,"threshold_uncertainty_score":0.002358973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01054657229788831,"score_gpt":0.286367481729522,"score_spread":0.2758209094316337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}