{"id":"W4282932245","doi":"10.1016/j.cell.2022.04.038","title":"Glioma progression is shaped by genetic evolution and microenvironment interactions","year":2022,"lang":"en","type":"article","venue":"Cell","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":498,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôpital de l'Enfant-Jésus","funders":"National Cancer Institute; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Brain Tumour Charity","keywords":"Biology; Glioma; Tumor microenvironment; Evolutionary biology; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000109476,0.00009237989,0.0001738071,0.0004204407,0.0001204865,0.0002681058,0.00007251409,0.0001269607,0.0004031269],"category_scores_gemma":[0.0002922489,0.00007709632,0.00008008991,0.0002694951,0.0001560139,0.0001304727,0.0001150967,0.0001334336,0.0001459096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001941854,"about_ca_system_score_gemma":0.0001443956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009956121,"about_ca_topic_score_gemma":0.002676829,"domain_scores_codex":[0.9999001,0.00002187808,0.000006520731,0.00002365535,0.00002556659,0.00002231402],"domain_scores_gemma":[0.9998549,0.00002491438,0.00007281691,0.00001001642,0.00001874019,0.00001862967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009044051,0.00004747229,0.361771,0.00005566856,0.00005289109,0.0009855893,0.000350632,0.0007051647,0.6102812,0.0003561205,0.0001085251,0.02438141],"study_design_scores_gemma":[0.000008254009,0.0002867308,0.9669275,0.0000048459,0.0000277796,0.00287164,0.0002413256,0.0009109958,0.02763095,0.0001832789,0.0008978515,0.000008767604],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991723,0.0003041822,0.0002102154,0.00001204342,6.39633e-7,0.000002453494,0.00004944091,0.000006293828,0.0002425282],"genre_scores_gemma":[0.9994267,0.0001574158,0.0001908583,0.000006894385,0.000001877766,0.000003039253,0.00008839006,0.000003233911,0.0001214646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009956121,"threshold_uncertainty_score":0.001979709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008026457329347212,"score_gpt":0.2453317587225771,"score_spread":0.2373053013932299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}