{"id":"W4282932245","doi":"10.1016/j.cell.2022.04.038","title":"Glioma progression is shaped by genetic evolution and microenvironment interactions","year":2022,"lang":"en","type":"article","venue":"Cell","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":498,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôpital de l'Enfant-Jésus","funders":"National Cancer Institute; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Brain Tumour Charity","keywords":"Biology; Glioma; Tumor microenvironment; Evolutionary biology; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00002127204,0.00006966222,0.00007844128,0.00004815116,0.0001397601,0.00000777879,0.00002193995,0.00001285187,0.001003512],"category_scores_gemma":[0.000001342214,0.00006088178,0.00003199542,0.00006154912,0.00001926253,0.00001645703,0.00006693569,0.00006608754,0.00004076433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001588572,"about_ca_system_score_gemma":0.000009028882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001955936,"about_ca_topic_score_gemma":7.239033e-7,"domain_scores_codex":[0.9994925,0.00001949629,0.00008929546,0.0001727106,0.0001231964,0.0001028465],"domain_scores_gemma":[0.9997619,0.00001085731,0.00003649044,0.0001170452,0.000005320437,0.00006839106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006460844,0.001719563,0.04733278,0.00003154018,0.00003601646,0.0001224643,0.0003224373,0.000005531859,0.9028823,0.000003293472,0.04251722,0.004962188],"study_design_scores_gemma":[0.006176353,0.002015168,0.2810635,0.00007091315,0.0004573326,0.0007037679,0.0008963209,0.002678468,0.3884315,0.00008950257,0.3171004,0.0003167271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934228,0.004644449,0.00003443175,0.001127295,0.00007913655,0.0002857193,0.00002184638,0.00001588917,0.0003684069],"genre_scores_gemma":[0.9984993,0.0000797218,0.0004195022,0.0001800549,0.0000196802,0.0001547627,0.00003885275,0.00001026106,0.0005978614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5144508,"threshold_uncertainty_score":0.9999097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008026457329347212,"score_gpt":0.2453317587225771,"score_spread":0.2373053013932299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}