{"id":"W4282933530","doi":"10.1093/humrep/deac110","title":"Polygenic embryo screening: four clinical considerations warrant further attention","year":2022,"lang":"en","type":"article","venue":"Human Reproduction","topic":"Reproductive Health and Technologies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Human Genome Research Institute; National Institutes of Health","keywords":"Warrant; Multidisciplinary approach; Psychology; Medicine; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001592759,0.0001469151,0.0003034803,0.0002369351,0.0009256054,0.00002042964,0.00006944191,0.00008278544,0.0005739891],"category_scores_gemma":[0.0007979652,0.0001441031,0.0001843907,0.0002837912,0.0001739872,0.00008852212,0.000114273,0.0006825248,0.00004816139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001021999,"about_ca_system_score_gemma":0.0001069616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005613021,"about_ca_topic_score_gemma":0.00000796365,"domain_scores_codex":[0.9974913,0.0002323935,0.0006179894,0.001003013,0.0003743856,0.0002809059],"domain_scores_gemma":[0.9982684,0.00003291013,0.0002359109,0.001196929,0.000183215,0.00008265969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001725828,0.003687314,0.4361453,0.0003967647,0.0008766782,0.0003963417,0.001607328,0.0002465277,0.2529819,0.03318901,0.1032762,0.1654708],"study_design_scores_gemma":[0.002016769,0.0016032,0.9389839,0.00002462498,0.0001858418,0.001924407,0.001800569,0.0000673197,0.001806324,0.008666775,0.04261727,0.0003029906],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687763,0.0006615006,0.0002604773,0.02645386,0.001190091,0.0009002048,0.000004329339,0.0005900867,0.001163151],"genre_scores_gemma":[0.9914813,0.00004124947,0.001557043,0.0003665746,0.001231625,0.0001779613,0.00005838165,0.00003268693,0.005053166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5028386,"threshold_uncertainty_score":0.7119102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1677508786340555,"score_gpt":0.3920680357100259,"score_spread":0.2243171570759703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}