{"id":"W4282933530","doi":"10.1093/humrep/deac110","title":"Polygenic embryo screening: four clinical considerations warrant further attention","year":2022,"lang":"en","type":"article","venue":"Human Reproduction","topic":"Reproductive Health and Technologies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Human Genome Research Institute; National Institutes of Health","keywords":"Warrant; Multidisciplinary approach; Psychology; Medicine; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007486701,0.0008371734,0.000899221,0.00184208,0.002192632,0.002781342,0.001697953,0.009571452,0.003634636],"category_scores_gemma":[0.03011336,0.0002986362,0.0008139407,0.001022393,0.003530288,0.003822826,0.001670382,0.007346842,0.0009295855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001760598,"about_ca_system_score_gemma":0.003530859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002708909,"about_ca_topic_score_gemma":0.005708207,"domain_scores_codex":[0.9953056,0.0019073,0.00083808,0.0004403889,0.001146853,0.0003618078],"domain_scores_gemma":[0.9794119,0.01257981,0.001377558,0.0006184072,0.004499192,0.001513143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003327586,0.0001648697,0.07401973,0.002126275,0.00008306906,0.1498297,0.003644143,0.0009128121,0.003753855,0.03699952,0.1823909,0.5457423],"study_design_scores_gemma":[0.0001439203,0.0004027661,0.03079693,0.006299568,0.0001965396,0.4583226,0.01487133,0.003187428,0.00233109,0.08958313,0.3935164,0.0003480751],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.02177711,0.08122695,0.02052791,0.8525068,0.006486821,0.0002397883,0.0001664244,0.0002648824,0.01680337],"genre_scores_gemma":[0.399171,0.1454566,0.08292653,0.3187302,0.04042449,0.0004491572,0.0006066407,0.0002797917,0.01195556],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.009571452,"threshold_uncertainty_score":0.03959394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1677508786340555,"score_gpt":0.3920680357100259,"score_spread":0.2243171570759703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}