{"id":"W4282934638","doi":"10.1158/1538-7445.am2022-1121","title":"Abstract 1121: Identification and <i>in vivo</i> validation of unique anti-oncogenic properties and mechanisms involving protein kinase signalling and autophagy mediated by the investigational new agent PV-10","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Cancer research; Aurora kinase; Melanoma; Kinase; Aurora A kinase; Cancer; Metastasis; Medicine; Biology; Cell cycle; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001547734,0.0003969054,0.0002324815,0.0001396031,0.0001120245,0.0002486811,0.0002243032,0.000235425,0.002144681],"category_scores_gemma":[0.000101309,0.0001067036,0.0001773529,0.0001734442,0.000204751,0.0001946247,0.00009829595,0.0006952318,0.000585634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003141473,"about_ca_system_score_gemma":0.0002847402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005580487,"about_ca_topic_score_gemma":0.0005839769,"domain_scores_codex":[0.9999002,0.00001644188,0.000008411932,0.00002072035,0.00002917689,0.00002494256],"domain_scores_gemma":[0.9999388,0.00001298739,0.00001607296,0.000009263168,0.000009024423,0.0000138065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004173806,0.0001082581,0.0001889338,0.00005391698,0.000005055912,0.00003267537,0.000008856249,0.00007750233,0.9972104,0.00007311488,0.000119005,0.00170476],"study_design_scores_gemma":[0.00004915213,0.001518342,0.001991529,0.000005138746,0.00001581789,0.0002292616,0.00001038602,0.0004623701,0.9937768,0.00001832047,0.001920006,0.000002877999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9895191,0.001816703,0.002652911,0.0001699572,0.0000525301,0.0001027071,0.001106875,0.00009379841,0.004485432],"genre_scores_gemma":[0.9854673,0.001871945,0.003287869,0.00008343157,0.00001829305,0.0001234745,0.003269645,0.00003229412,0.00584567],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002144681,"threshold_uncertainty_score":0.00717473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09095453036064802,"score_gpt":0.3369726718432445,"score_spread":0.2460181414825965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}