{"id":"W4282936598","doi":"10.1158/1538-7445.am2022-5616","title":"Abstract 5616: Tumor-targeted immune activation via a site-specific TLR7-agonist antibody-drug conjugate","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Micropharma (Canada)","funders":"","keywords":"Agonist; Immune system; Conjugate; Chemistry; Antibody; In vivo; Systemic administration; Pharmacology; Biology; Biochemistry; Immunology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000248528,0.0003891944,0.0002526006,0.0002654977,0.0000835553,0.000188738,0.0002528196,0.0003650112,0.001060756],"category_scores_gemma":[0.0001795297,0.0001344014,0.0001927951,0.0001640518,0.0001285594,0.000179122,0.00020491,0.0004070553,0.0005222084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002477839,"about_ca_system_score_gemma":0.0002153811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002119538,"about_ca_topic_score_gemma":0.0003102275,"domain_scores_codex":[0.9998017,0.00003142914,0.00002059499,0.0000415922,0.00006247881,0.0000422266],"domain_scores_gemma":[0.999908,0.00001016402,0.00002976975,0.000008718212,0.00002365899,0.00001974699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005434205,0.00004980277,0.0001170235,0.000054612,0.000005991646,0.00003453259,0.000007624577,0.0002124184,0.997716,0.00007746696,0.00007386369,0.001596424],"study_design_scores_gemma":[0.00001317219,0.0004582879,0.000252974,0.00000338967,0.000007446504,0.00009524782,0.000002983473,0.0005751423,0.9968047,0.000009087687,0.001774408,0.000003042705],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9865455,0.001896686,0.007962366,0.0001215909,0.00004472131,0.0002172376,0.0003985441,0.0001032724,0.00271015],"genre_scores_gemma":[0.9834567,0.0008680583,0.01080891,0.00007364709,0.000009999935,0.0001148981,0.0006250529,0.0000235507,0.004019337],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.001060756,"threshold_uncertainty_score":0.003548563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08176485321994376,"score_gpt":0.4318421477716949,"score_spread":0.3500772945517511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}