{"id":"W4282936736","doi":"10.1158/1538-7445.am2022-5990","title":"Abstract 5990: Targeted nanoparticles reduce tumor progression and lung metastasis by limiting DNA damage repair and immune suppression in metastatic triple-negative breast cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Olaparib; Cancer research; PARP inhibitor; PARP1; Biology; Medicine; Poly ADP ribose polymerase; Biochemistry; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006380011,0.0001997863,0.0001920106,0.0001152153,0.00005695412,0.0001320369,0.0001227185,0.0002558276,0.001071182],"category_scores_gemma":[0.00004829924,0.00008268271,0.000144193,0.00006350796,0.00008289445,0.0001143857,0.0001091284,0.0002651635,0.0002930279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001700411,"about_ca_system_score_gemma":0.0001396823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000545606,"about_ca_topic_score_gemma":0.0006783637,"domain_scores_codex":[0.9999515,0.000006352377,0.000003003141,0.00001073896,0.00001811624,0.00001027658],"domain_scores_gemma":[0.9999804,0.000002834854,0.000005521328,0.0000012322,0.000003801969,0.000006197125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001269535,0.00007730196,0.00007345164,0.00004933135,0.000006292206,0.00002169211,0.000007272552,0.0001294691,0.9963498,0.00005094304,0.0001385896,0.002968966],"study_design_scores_gemma":[0.0000784689,0.001868129,0.002165535,0.000009976182,0.00003075601,0.0002437577,0.00001417423,0.001743721,0.9907961,0.00003649154,0.003008231,0.000004747138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992783,0.002131812,0.002526113,0.0001191519,0.00005166497,0.00003518487,0.0001380821,0.00009215074,0.00212281],"genre_scores_gemma":[0.9940321,0.0007793173,0.001755247,0.00009743436,0.00001070434,0.00002840631,0.000189903,0.00001510277,0.003091864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001071182,"threshold_uncertainty_score":0.003583491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05990157005565653,"score_gpt":0.4212244016056191,"score_spread":0.3613228315499625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}