{"id":"W4282940533","doi":"10.1161/hypertensionaha.122.19324","title":"Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension","year":2022,"lang":"en","type":"review","venue":"Hypertension","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Human Genome Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Medical Research Council; National Institute on Aging; National Cancer Institute; National Institutes of Health; U.S. Department of Veterans Affairs","keywords":"Blood pressure; Internal medicine; Biobank; Medicine; Exome sequencing; 1000 Genomes Project; Genetics; Biology; Cardiology; Single-nucleotide polymorphism; Gene; Genotype; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003397519,0.0006582751,0.002421277,0.0002166526,0.0003396792,0.00002355918,0.0004333361,0.0007413589,0.00002706397],"category_scores_gemma":[0.0003188524,0.0005495671,0.0003734895,0.0002729932,0.0000741656,0.000007629962,0.0009054577,0.0004704412,0.000006530412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001136755,"about_ca_system_score_gemma":0.0002161382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005860555,"about_ca_topic_score_gemma":0.0001245351,"domain_scores_codex":[0.9956728,0.00106632,0.00108992,0.001331751,0.0003537716,0.0004854604],"domain_scores_gemma":[0.9974144,0.0002024556,0.0008420454,0.0011881,0.0001710139,0.0001819574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007195435,0.03710254,0.006442878,0.05007281,0.1203996,0.001908532,0.009807128,0.002577105,0.5007907,0.0001173307,0.0126422,0.2574196],"study_design_scores_gemma":[0.001754543,0.001142907,0.001101949,0.0006903682,0.02722401,0.0003290927,0.0006124499,0.0001574733,0.00004858301,0.00001963319,0.9661991,0.0007198755],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1354311,0.8625402,0.00001086222,0.000007421419,0.0002493921,0.001171872,0.00049389,0.00002643604,0.00006883937],"genre_scores_gemma":[0.1352417,0.8616992,0.0002640432,0.0001221406,0.0002947099,0.0002156261,0.001790769,0.0001151777,0.0002565959],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9535569,"threshold_uncertainty_score":0.9996956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04298919705259378,"score_gpt":0.2649400094073404,"score_spread":0.2219508123547466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}