{"id":"W4282940533","doi":"10.1161/hypertensionaha.122.19324","title":"Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension","year":2022,"lang":"en","type":"review","venue":"Hypertension","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Human Genome Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Medical Research Council; National Institute on Aging; National Cancer Institute; National Institutes of Health; U.S. Department of Veterans Affairs","keywords":"Blood pressure; Internal medicine; Biobank; Medicine; Exome sequencing; 1000 Genomes Project; Genetics; Biology; Cardiology; Single-nucleotide polymorphism; Gene; Genotype; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004625376,0.0009127189,0.0007860452,0.001158946,0.000566644,0.001104468,0.0006786032,0.000853608,0.001571636],"category_scores_gemma":[0.007897228,0.0004688672,0.002326685,0.00169411,0.0004537853,0.0004944102,0.001188226,0.001124081,0.0001054485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002834777,"about_ca_system_score_gemma":0.0008697664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007067305,"about_ca_topic_score_gemma":0.0159669,"domain_scores_codex":[0.9977903,0.001150369,0.0001302527,0.0005366472,0.0002243718,0.0001680329],"domain_scores_gemma":[0.9942391,0.003428226,0.0007625308,0.0007245133,0.0003362338,0.0005093773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001489364,0.0001340922,0.9285036,0.0005509767,0.01771897,0.001636073,0.00103356,0.001457249,0.01615082,0.0009822906,0.001900731,0.02844233],"study_design_scores_gemma":[0.0001380122,0.0003008544,0.9820505,0.0001398173,0.009255344,0.000804834,0.0003534585,0.00141749,0.000776975,0.002746606,0.001980608,0.00003554601],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.977778,0.009108123,0.007247183,0.002289108,0.0001124098,0.00003270282,0.002064529,0.00006646673,0.001301393],"genre_scores_gemma":[0.9940913,0.001361149,0.002748614,0.0006247773,0.00008623233,0.00002800699,0.000825776,0.00001945025,0.0002146005],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.007067305,"threshold_uncertainty_score":0.02446163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04298919705259378,"score_gpt":0.2649400094073404,"score_spread":0.2219508123547466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}