{"id":"W4282941061","doi":"10.3390/biom12050643","title":"Hinokiflavone Inhibits MDM2 Activity by Targeting the MDM2-MDMX RING Domain","year":2022,"lang":"en","type":"article","venue":"Biomolecules","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"York University","keywords":"MDMX; Mdm2; Cancer research; Oncogene; Downregulation and upregulation; Suppressor; Apoptosis; Cancer; Ubiquitin; Cell cycle; Cancer cell; Chemistry; Cell biology; Biology; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005826465,0.0002172625,0.0001550008,0.0001826581,0.0000775279,0.000106477,0.0001173591,0.0001129063,0.001031177],"category_scores_gemma":[0.00005427617,0.00005380033,0.0001244324,0.0001047887,0.0000753928,0.00007697518,0.000119726,0.0002128257,0.0001496534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009266902,"about_ca_system_score_gemma":0.00008342179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003222493,"about_ca_topic_score_gemma":0.0008470179,"domain_scores_codex":[0.9999741,0.000005839227,0.000002554338,0.000004719145,0.000005318893,0.000007432242],"domain_scores_gemma":[0.9999797,0.00000394831,0.000005971745,0.000002056375,0.000002645751,0.000005630318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003153664,0.00009709693,0.0005884598,0.0001363272,0.00002033307,0.0001416778,0.000009994814,0.0003363122,0.9856997,0.000126792,0.0001200341,0.01240781],"study_design_scores_gemma":[0.00008000909,0.001702178,0.006807268,0.00001633835,0.00003946793,0.0006152458,0.00002369982,0.0006299164,0.9808307,0.00007808989,0.00916784,0.000009234031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855857,0.008217217,0.002850175,0.0001028568,0.00002959225,0.00007029584,0.0003820867,0.00008899321,0.002673057],"genre_scores_gemma":[0.9939249,0.002633681,0.001259457,0.00005083365,0.000007105858,0.00001529374,0.0003289228,0.000003219005,0.001776516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001031177,"threshold_uncertainty_score":0.003449678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008899778407690918,"score_gpt":0.236315993476628,"score_spread":0.2274162150689371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}