{"id":"W4282941061","doi":"10.3390/biom12050643","title":"Hinokiflavone Inhibits MDM2 Activity by Targeting the MDM2-MDMX RING Domain","year":2022,"lang":"en","type":"article","venue":"Biomolecules","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"York University","keywords":"MDMX; Mdm2; Cancer research; Oncogene; Downregulation and upregulation; Suppressor; Apoptosis; Cancer; Ubiquitin; Cell cycle; Cancer cell; Chemistry; Cell biology; Biology; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005833076,0.000268528,0.0002994675,0.0001216762,0.0006205256,0.00004431236,0.0002597058,0.00009239435,0.0002798955],"category_scores_gemma":[0.00012633,0.0002261656,0.0001980688,0.0005909658,0.0001876303,0.00006182948,0.0004376932,0.000647027,0.00004816956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003812969,"about_ca_system_score_gemma":0.0001678105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002981198,"about_ca_topic_score_gemma":0.00001915203,"domain_scores_codex":[0.9977112,0.0002640559,0.000288933,0.0005123982,0.0007020267,0.0005213536],"domain_scores_gemma":[0.9990056,0.00007384497,0.000172422,0.0005331394,0.00005397313,0.0001610303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001734564,0.000186376,0.0001235565,0.00003103585,0.00009679372,0.0001558574,0.0004555984,0.00003127786,0.9731861,0.0004070897,0.02021302,0.004939843],"study_design_scores_gemma":[0.002182298,0.0003311045,0.0004350982,0.0000623829,0.0001185227,0.000270451,0.0008473091,0.000431771,0.8313012,0.0001913332,0.1634061,0.0004224685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803661,0.005189474,0.00338459,0.005601131,0.0004620086,0.0007051697,0.0001053039,0.0002348605,0.003951359],"genre_scores_gemma":[0.9973723,0.00005871056,0.0006233201,0.0009994253,0.0001635388,0.0001348641,0.00009420372,0.00007877347,0.0004748194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1431931,"threshold_uncertainty_score":0.9222767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008899778407690918,"score_gpt":0.236315993476628,"score_spread":0.2274162150689371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}