{"id":"W4282941443","doi":"10.1093/nar/gkac411","title":"Transcription feedback dynamics in the wake of cytoplasmic mRNA degradation shutdown","year":2022,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation","keywords":"Biology; Messenger RNA; Exonuclease; Transcription (linguistics); Cell biology; Nonsense-mediated decay; Molecular biology; RNA; Genetics; RNA splicing; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001371579,0.0001568405,0.0003670893,0.0001369907,0.0001544934,0.0004376065,0.0001756539,0.0002208172,0.001240938],"category_scores_gemma":[0.0003222902,0.0001274213,0.000160578,0.0001178229,0.0002704835,0.0003295069,0.0002525549,0.0005320779,0.0003495552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004612892,"about_ca_system_score_gemma":0.0002278618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007587532,"about_ca_topic_score_gemma":0.0008175241,"domain_scores_codex":[0.9998864,0.000006996282,0.00000520504,0.00004087733,0.0000391439,0.0000213584],"domain_scores_gemma":[0.9998233,0.00003608254,0.0000364035,0.00001359287,0.00004940928,0.00004128064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002284044,0.00001617078,0.002201002,0.00003199043,0.000005877145,0.0001874433,0.0001095561,0.0004468837,0.9927527,0.0003437993,0.0001003081,0.003575977],"study_design_scores_gemma":[0.00002774071,0.0004440186,0.08630041,0.00002269819,0.00002844784,0.0003718291,0.000416,0.01838254,0.8877563,0.001308575,0.004904144,0.00003735261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899521,0.001563326,0.006200849,0.0002028396,0.00005431057,0.00001488334,0.0003002765,0.0002903685,0.001420973],"genre_scores_gemma":[0.997612,0.0002333032,0.0008394363,0.00006027801,0.00001389617,0.00001285435,0.0002194902,0.00002376807,0.0009849573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001240938,"threshold_uncertainty_score":0.004151344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03133461231088534,"score_gpt":0.313380140358984,"score_spread":0.2820455280480987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}