{"id":"W4282944683","doi":"10.1016/j.ydbio.2022.05.010","title":"Temporal cell fate determination in the spinal cord is mediated by the duration of Notch signalling","year":2022,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Notch signaling pathway; Biology; Progenitor cell; Cell fate determination; Cell biology; Interneuron; Signalling; Zebrafish; Neuroscience; HES1; Neural stem cell; Neurogenesis; Transcription factor; Signal transduction; Stem cell; Genetics; Inhibitory postsynaptic potential; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005643209,0.0001186285,0.0001042218,0.00004778552,0.0002138698,0.000005928265,0.0002819462,0.0001000315,0.00005543789],"category_scores_gemma":[0.00002019821,0.00008240776,0.00003748278,0.0001811116,0.0001144491,0.000004371559,0.0001438414,0.000117883,0.000006217722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003901414,"about_ca_system_score_gemma":0.00008762824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003866545,"about_ca_topic_score_gemma":0.00004550034,"domain_scores_codex":[0.9988846,0.0002656251,0.0003284836,0.0002441358,0.0001037987,0.0001734055],"domain_scores_gemma":[0.9996698,0.00002595278,0.0001670408,0.00009528056,0.00002702308,0.00001492469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003013137,0.00006257324,0.03151314,0.000005825108,0.0000146072,0.000001193655,0.0003262913,0.000003868892,0.9584161,0.00001716763,0.001010752,0.008327187],"study_design_scores_gemma":[0.0007970216,0.001004538,0.04084264,0.000005113757,0.000008678005,0.00006638133,0.001567067,0.0001060046,0.9208441,0.0001828607,0.03432259,0.000252938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980015,0.0003783201,0.0002955867,0.0005687292,0.0001291791,0.000262259,0.00004795594,0.000004241684,0.000312278],"genre_scores_gemma":[0.9966146,0.00003755958,0.0003676148,0.000950937,0.00002074035,0.0000885136,0.001777884,0.000006502951,0.0001355883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03757191,"threshold_uncertainty_score":0.3360491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01247063177895984,"score_gpt":0.2543042030198826,"score_spread":0.2418335712409228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}