{"id":"W4282945728","doi":"10.1158/1078-0432.ccr-22-0541","title":"PD-L1 Crosslinking as a New Strategy of 4-1BB Agonism Immunotherapy","year":2022,"lang":"en","type":"letter","venue":"Clinical Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NYU Grossman School of Medicine; York University; U.S. Department of Veterans Affairs","keywords":"Immunotherapy; Agonism; Cancer immunotherapy; Tumor microenvironment; Immune system; Cancer research; Medicine; Immunology; Political science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006407981,0.0004533067,0.0005107803,0.0002879957,0.0005450657,0.0008730582,0.0003933037,0.006079709,0.001582879],"category_scores_gemma":[0.001180556,0.0002290354,0.0005659256,0.0001443236,0.001091787,0.0009877251,0.0003898678,0.007287225,0.001785769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001127711,"about_ca_system_score_gemma":0.0004092995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001674982,"about_ca_topic_score_gemma":0.0004445702,"domain_scores_codex":[0.9996297,0.000129168,0.00003007828,0.00005534818,0.0001067432,0.00004895707],"domain_scores_gemma":[0.9997043,0.0001802287,0.00001930341,0.00002221792,0.00003003236,0.0000438541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00171484,0.001041594,0.001946621,0.001196598,0.00014696,0.04098391,0.0003495955,0.002749952,0.0401753,0.05598823,0.5709291,0.2827772],"study_design_scores_gemma":[0.001104266,0.0009773597,0.001151359,0.0002164451,0.00006305126,0.027049,0.0001084117,0.003237316,0.01663696,0.03523409,0.914154,0.00006781724],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.03794711,0.09726553,0.01400007,0.760276,0.04826229,0.0004106377,0.0001911111,0.0006485874,0.04099874],"genre_scores_gemma":[0.2601124,0.06615692,0.0121627,0.5338734,0.08027259,0.0007086658,0.0001832085,0.000116141,0.046414],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.006079709,"threshold_uncertainty_score":0.008182108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3209360935131581,"score_gpt":0.5552180262642052,"score_spread":0.2342819327510471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}