{"id":"W4282945862","doi":"10.1002/cmdc.202200259","title":"Druggability Evaluation of the Neuron Derived Orphan Receptor (NOR‐1) Reveals Inverse NOR‐1 Agonists","year":2022,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Aventis Foundation; European Commission; European Federation of Pharmaceutical Industries and Associations; McGill University; Diamond Light Source; Innovative Medicines Initiative","keywords":"Druggability; Orphan receptor; Inverse agonist; Computational biology; Neuron-derived orphan receptor 1; Pharmacology; Biology; Receptor; Chemistry; Stereochemistry; Genetics; Nuclear receptor; Gene; Agonist","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000119338,0.0003036906,0.0002460456,0.0001656439,0.0001021384,0.0001969796,0.0001755282,0.0001813467,0.001704482],"category_scores_gemma":[0.0001600053,0.00009016202,0.0001567051,0.0001159054,0.0001903155,0.0001222946,0.0001624027,0.0003397352,0.0003948531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002063099,"about_ca_system_score_gemma":0.0001581229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005124874,"about_ca_topic_score_gemma":0.001285649,"domain_scores_codex":[0.9998986,0.00002026859,0.000007754546,0.00002261686,0.00002569017,0.00002505663],"domain_scores_gemma":[0.9999242,0.00002207,0.00001333107,0.000009994486,0.00001292327,0.00001748789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001272455,0.000042888,0.0001091532,0.00003688112,0.000003463364,0.0000364721,0.00002404739,0.0002003664,0.9967368,0.00007198633,0.00004203449,0.002568642],"study_design_scores_gemma":[0.00001607429,0.001777775,0.001017853,0.000006731006,0.00001361,0.0001087444,0.000023079,0.0003965651,0.9948225,0.00002318598,0.00178743,0.000006405282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933826,0.00178213,0.001714154,0.00007266195,0.00002007144,0.00006101089,0.0003180913,0.00005103546,0.002598417],"genre_scores_gemma":[0.9889274,0.002327846,0.003180563,0.00006577706,0.000008028209,0.00006847564,0.0005950115,0.00002408701,0.004802977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001704482,"threshold_uncertainty_score":0.005702078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06452013212660444,"score_gpt":0.2799664783148323,"score_spread":0.2154463461882278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}