{"id":"W4282945862","doi":"10.1002/cmdc.202200259","title":"Druggability Evaluation of the Neuron Derived Orphan Receptor (NOR‐1) Reveals Inverse NOR‐1 Agonists","year":2022,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Aventis Foundation; European Commission; European Federation of Pharmaceutical Industries and Associations; McGill University; Diamond Light Source; Innovative Medicines Initiative","keywords":"Druggability; Orphan receptor; Inverse agonist; Computational biology; Neuron-derived orphan receptor 1; Pharmacology; Biology; Receptor; Chemistry; Stereochemistry; Genetics; Nuclear receptor; Gene; Agonist","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001369819,0.0001594373,0.0002107262,0.00004191193,0.0004666687,0.0000269793,0.0005989402,0.00004935515,0.003317314],"category_scores_gemma":[0.001377401,0.0001339745,0.0001611458,0.0005125969,0.0002122975,0.0001016053,0.0004358321,0.0003347759,0.00004840614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002752604,"about_ca_system_score_gemma":0.000157683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002516278,"about_ca_topic_score_gemma":0.00000440311,"domain_scores_codex":[0.9970477,0.0007790573,0.0003517818,0.0004860856,0.001058356,0.0002770459],"domain_scores_gemma":[0.9987444,0.0001846033,0.0002826456,0.0005976714,0.0001061193,0.00008461969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003558731,0.0001128734,0.0009099891,0.00002223707,0.000003425153,5.237467e-7,0.0008941776,0.0001600008,0.9916198,0.00006647437,0.003813205,0.002361705],"study_design_scores_gemma":[0.0004932479,0.00004572536,0.001494783,0.00001036538,0.00002818922,0.000005039103,0.000256471,0.00160108,0.9885756,0.0005675229,0.006779099,0.0001428842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958438,0.00002293618,0.000003356564,0.0007578936,0.0007746972,0.0005395816,0.0000420507,0.0000491312,0.001966556],"genre_scores_gemma":[0.9985211,0.000005859873,0.00006581088,0.0007553882,0.00007300869,0.00007196051,0.000007742818,0.00003041797,0.0004687059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003268908,"threshold_uncertainty_score":0.9975938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06452013212660444,"score_gpt":0.2799664783148323,"score_spread":0.2154463461882278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}