{"id":"W4282946071","doi":"10.1172/jci154317","title":"The neuronal tyrosine kinase receptor ligand ALKAL2 mediates persistent pain","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary; Alberta Children's Hospital","funders":"Alberta Children's Hospital Research Institute; Canada Research Chairs; Crohn's and Colitis Canada; Canadian Institutes of Health Research; Agence de la Biomédecine; University of Calgary","keywords":"Receptor tyrosine kinase; Tyrosine kinase; ROR1; Tropomyosin receptor kinase C; Receptor; Receptor Protein-Tyrosine Kinases; Ligand (biochemistry); Medicine; Chemistry; Cell biology; Biology; Internal medicine; Platelet-derived growth factor receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009569008,0.0003910687,0.000236668,0.00012129,0.0001955177,0.0004381767,0.0001837651,0.0002827047,0.002279849],"category_scores_gemma":[0.0001008952,0.00008856392,0.0001992986,0.0001256125,0.0002142419,0.0003158088,0.0003175436,0.0006287852,0.0006138126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000352647,"about_ca_system_score_gemma":0.000240592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004646973,"about_ca_topic_score_gemma":0.0009353404,"domain_scores_codex":[0.9999239,0.00001437495,0.000004814919,0.00001434125,0.00001730113,0.00002529872],"domain_scores_gemma":[0.9999621,0.000004366233,0.00001195452,0.000003075828,0.00000614388,0.00001238892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005456813,0.00006624861,0.001321368,0.0003127231,0.00003257323,0.0005939866,0.00003585478,0.0001886384,0.987288,0.0005502961,0.0006712955,0.008393259],"study_design_scores_gemma":[0.0003310271,0.002901966,0.06482021,0.0001492398,0.0002571481,0.008085666,0.0005499416,0.005106488,0.8667729,0.001627242,0.04934419,0.00005390183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9499901,0.03184418,0.00435969,0.001161628,0.0001808493,0.0000715555,0.000775719,0.0001883353,0.01142789],"genre_scores_gemma":[0.9904107,0.005770301,0.0004835427,0.0001468169,0.00003424282,0.00002101735,0.0003058813,0.000008502668,0.002819043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002279849,"threshold_uncertainty_score":0.007626832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07057905906645386,"score_gpt":0.3428778714697414,"score_spread":0.2722988124032876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}