{"id":"W4282946315","doi":"10.1158/1538-7445.am2022-ct012","title":"Abstract CT012: Nivolumab (NIVO) + platinum-doublet chemotherapy (chemo) vs chemo as neoadjuvant treatment for resectable (IB-IIIA) non-small cell lung cancer (NSCLC): Event-free survival (EFS) results from the phase 3 CheckMate 816 trial","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Diagnosis and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal; McGill University","funders":"","keywords":"Medicine; Internal medicine; Clinical endpoint; Oncology; Lung cancer; Nivolumab; Population; Interim analysis; Neoadjuvant therapy; Randomized controlled trial; Odds ratio; Surrogate endpoint; Cancer; Breast cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001484836,0.0009153438,0.001357606,0.0002146778,0.0002673191,0.0008725484,0.0007325644,0.000968308,0.00864269],"category_scores_gemma":[0.001482176,0.0002504049,0.00198071,0.0003328825,0.0005907622,0.0006156531,0.0002969155,0.002213547,0.0009379738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009386342,"about_ca_system_score_gemma":0.0009564629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001032476,"about_ca_topic_score_gemma":0.003708638,"domain_scores_codex":[0.9995199,0.000314999,0.0000284584,0.00006029126,0.00003624757,0.00004003384],"domain_scores_gemma":[0.999331,0.0002055223,0.0001708728,0.0000446493,0.00004131457,0.0002066798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9730364,0.001872288,0.00105439,0.0007623946,0.0009586787,0.00002487408,0.00002578904,0.000445563,0.00280634,0.0001703106,0.002147949,0.01669493],"study_design_scores_gemma":[0.9118646,0.07722851,0.005247442,0.0001338709,0.001633198,0.00006925689,0.00002897884,0.0007991914,0.001080534,0.0003463532,0.001547682,0.00002044414],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9724439,0.009028222,0.0008381793,0.001416557,0.0007966167,0.002616951,0.004763616,0.0001816915,0.007914228],"genre_scores_gemma":[0.9832289,0.001979023,0.001139373,0.001538978,0.0004498229,0.002210114,0.004412061,0.00002735295,0.005014356],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.00864269,"threshold_uncertainty_score":0.02891272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08247936788751797,"score_gpt":0.4200530820552216,"score_spread":0.3375737141677036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}